There is an abundance of evidence indicating that the oral administration of sodium (13I)I-iodide is of value in the management of well-differentiated thyroid cancers. The first step in the management of thyroid cancer is near-total removal of the thyroid gland. Destroying any residual functioning thyroid tissue in the neck or metastatic tissue elsewhere in the body using (131)I after surgery d...

BACKGROUND Serum miRNAs profiles between papillary thyroid carcinoma (PTC) patients with non-(131)I and (131)I-avid lung metastases are differentially expressed. These miRNAs have to be further validated and the role of these miRNAs in the molecular function level of thyroid cancer cell lines has not been investigated. METHODS Expression levels of six identified miRNAs were assessed via quant...

The aberrant expression of human sodium iodide symporter (NIS) in breast cancer (BC) has raised the possibility of using targeted radioiodide therapy. Here we investigate modulation of endogenous, functional NIS expression by histone deacetylase inhibitors (HDACi) in vitro and in vivo. Luciferase reporter based initial screening of six different HDACi shows 2-10 fold enhancement of NIS promoter...

DETECTOR RESOLUTION Resolution is a measure of the width (full width half max) of a single energy peak at a specific energy, either expressed in absolute keV (as with Germanium Detectors), or as a percentage of the energy at that point (Sodium Iodide Detectors). Better (lower FWHM value) resolution enables the system to more clearly separate the peaks within a spectrum. Figure 1.2 shows two spe...

DETECTOR RESOLUTION Resolution is a measure of the width (full width half max) of a single energy peak at a specific energy, either expressed in absolute keV (as with Germanium Detectors), or as a percentage of the energy at that point (Sodium Iodide Detectors). Better (lower FWHM value) resolution enables the system to more clearly separate the peaks within a spectrum. Figure 1.2 shows two spe...

UNLABELLED The purpose of this study was to investigate the enhanced therapeutic effect of the combined use of shRNA (small hairpin RNA) therapy for the hexokinase II (HKII) gene and (131)I human sodium iodide symporter (hNIS) as a gene therapy for in vitro and in vivo treatment of anaplastic thyroid carcinoma cells (ARO) in an animal model. METHODS A recombinant lentivirus containing a plasm...

We recently demonstrated tumor-selective iodide uptake and therapeutic efficacy of combined radiovirotherapy after systemic delivery of the theranostic sodium iodide symporter (NIS) gene using a dendrimer-coated adenovirus. To further improve shielding and targeting we physically coated replication-selective adenoviruses carrying the hNIS gene with a conjugate consisting of cationic poly(amidoa...

We report the sum frequency generation (SFG) spectra of aqueous sodium iodide interfaces computed with the methodology outlined by Morita and Hynes (J. Phys. Chem. B 2002, 106, 673), which is based on molecular dynamics simulations. The calculated spectra are in qualitative agreement with experiment. Our simulations show that the addition of sodium iodide to water leads to an increase in SFG in...