Nucleus accumbens-associated protein 1 (NAC1), a transcriptional co-regulator, is overexpressed in advanced prostate cancer. However, the NAC1-regulated transcriptome has not been completely explored. In the present study, the functional silencing of NAC1 blocked the migration of prostate cancer cells and suppress osteoclastogenesis. The present study also determined that NAC1 was overexpressed...

Nac1 is a POZ-domain transcription factor that is involved in the self-renewal of embryonic stem cells. It is overexpressed in ovarian serous carcinoma and targeting the interactions of its POZ domain is a potential therapeutic strategy. Nac1 lacks a zinc-finger DNA-binding domain and thereby differs from most other POZ-domain transcription factors. Here, the crystal structure of the Nac1 POZ d...

Coordinated proteolysis of synaptic proteins is required for synaptic plasticity, but a mechanism for recruiting the ubiquitin-proteasome system (UPS) into dendritic spines is not known. NAC1 is a cocaine-regulated transcriptional protein that was found to complex with proteins in the UPS, including cullins and Mov34. NAC1 and the proteasome were cotranslocated from the nucleus into dendritic s...

Nac1 (nucleus accumbens 1) is a POZ (poxvirus and zinc finger)-domain transcriptional repressor that is expressed at high levels in ovarian serous carcinoma. Here we identify Nac1 as a novel interacting partner of the POZ-domain transcriptional activator, Miz1 (Myc-interacting zinc-finger protein 1), and using chemical crosslinking we show that this association is mediated by a heterodimeric in...

peppermint (mentha piperita l.) is one of the most important plants producing essential oil. an experiment was carried out using a randomized complete block design with 3 replications to study the effect of salinity stress on growth parameters, essential oil percent of peppermint. 4 levels of salinity solution containing 0, 50, 100 and 200 mmol nacl was applied in irrigation plantings in a gree...

crisis due to global warming and its associated damaging consequences, including salinity, it is essential to develop plant resistance to salinity level. in this study, an experiment was conducted using different levels of salinity (0.05, 0.1, 0.15 and 0.2% sodium chloride) had on rosa hybrida, as the most important cut flowers in the world. results showed that by increasing of salinity, sodium...

A pure sodium chloride solution, at the concentration in which this salt exists in sea-water, may be poisonous to marine organisms, as was first proven by Loeb,’ who found that the young of a marine fish (Fundulus) soon die in y to F solution of sodium chloride. That death is due to the poisonous action of the sodium chloride, and not merely to the absence of other constituents of the sea-water...

Diets high in sucrose or fructose have been shown by others to induce a modest elevation of blood pressure in rats. The present experiments were conducted to determine whether the sucrose-induced increase of blood pressure is dependent on the intake of sodium chloride. Four groups of Sprague-Dawley rats were studied: 1) a group maintained on a low salt diet and distilled water (0.45% sodium chl...

Salinization of surface water from sodium chloride (road salt) applied to paved roads is a widely recognized environmental concern in the northern hemisphere, yet practical information to improve winter road management to reduce the environmental impacts of this deicer is lacking. The purpose of our study was to provide such information by developing baseline concentrations for sodium and chlor...

The survival of Salmonella typhimurium (ATCC 13311) heated and recovered in media with 0, 1, 2, 3, 4 or 5% (w/w) added sodium chloride was investigated. A protective effect in the heating medium and an inhibitory effect in the recovery medium were observed. The results showed an interaction between the effect on, D(58 degrees C) values, of sodium chloride concentration in both media. Lower conc...