نتایج جستجو برای: smooth muscle contraction

تعداد نتایج: 417858  

Journal: :General physiology and biophysics 2013
Sachie K Ogawa Min-Chul Shin Masaki Hirashima Norio Akaike Yushi Ito

Selenoprotein P (SeP) not only represents the major selenoprotein in plasma, but also provides more than 50% of the total plasma selenium. However, there is no report concerning the direct action of selenium or selenium-containing compounds on the contraction and relaxation of the airway smooth muscle. Therefore, we investigated the effects of SeP and sodium selenite (SS) on the indirectly indu...

Journal: :Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi 2004
Yoshihiko Chiba Miwa Misawa

Smooth muscle contraction is mediated by Ca2+-dependent and Ca2+-independent pathways. The latter Ca2+-independent pathway, termed Ca2+ sensitization, is mainly regulated by a monomeric GTP binding protein RhoA and its downstream target Rho-kinase. Recent studies suggest a possible involvement of augmented RhoA/Rho-kinase signaling in the elevated smooth muscle contraction in several human dise...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1984
W G Kerrick L Y Bourguignon

Several characteristics of receptor capping in lymphocyte membranes suggest similarities with mechanisms underlying control of contraction in smooth muscle fibers. Both capping and contraction are Ca2+ dependent and require metabolic energy. Contractile proteins such as actin and myosin are associated with the cap, as is calmodulin, which mediates the Ca2+ dependence of smooth muscle contractio...

2017
Ancy D Nalli Hongxia Wang Sayak Bhattacharya Bryan A Blakeney Karnam S Murthy

Hydrogen sulfide (H2 S) plays an important role in smooth muscle relaxation. Here, we investigated the expression of enzymes in H2 S synthesis and the mechanism regulating colonic smooth muscle function by H2 S. Expression of cystathionine-γ-lyase (CSE), but not cystathionine-β-synthase (CBS), was identified in the colonic smooth muscle of rabbit, mouse, and human. Carbachol (CCh)-induced contr...

Journal: :European journal of pharmacology 2004
Reinoud Gosens Dedmer Schaafsma Mechteld M Grootte Bromhaar Bart Vrugt Johan Zaagsma Herman Meurs S Adriaan Nelemans

Growth factors have been implicated in the pathophysiology of asthma. However, the putative effects of these growth factors on human airway smooth muscle tone are still largely unknown. We performed contraction experiments using human bronchial smooth muscle ring preparations. The growth factor insulin-like growth factor-1 (IGF-1) induced a slowly developing sustained contraction, which was dep...

Journal: :iranian journal of allergy, asthma and immunology 0
edibe karasu-minareci akdeniz university, school of medicine, pharmacology department, antalya, turkey yasemin kaya akdeniz university, school of medicine, anatomy department, antalya, turkey fatos belgin yildirim akdeniz university, school of medicine, anatomy department, antalya, turkey

asthma  is a clinical syndrome  characterized by chronic  airway inflammation, airway responsiveness, and expiratory airflow limitation. nocturnal symptoms and decreases in lung function are common aspects of the asthma clinical syndrome. nocturnal symptoms also appear to be associated with asthma-related mortality. in addition to its importance to the regulation of human circadian rhythms, an ...

Journal: :Life sciences 1992
K N Bitar S Stein G M Omann

Endothelin is a potent vasoconstrictor peptide which has recently been localized in the gastrointestinal tract. We have investigated the transmembrane signaling properties of endothelin in isolated smooth muscle cells of the rabbit rectosigmoid. Endothelin induced a dose dependent contraction of smooth muscle cells in a range of 10(-10) to 10(-6)M. In normal buffer, contraction peaked at 30 sec...

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