SMARCA4 (also known as BRG1) and SMARCB1 are proteins with transcription-regulation through helicase ATPase activity in the SWI/SNF chromatin-remodelling complex. Alterations these genes have been described prognostic related to tumor differentiation metastasis. Inactivation has a role development, early dedifferentiation metastasis of up 20% solid tumors. We performed an observational retrospe...

BackgroundNon-small cell lung cancer (NSCLC) patients with high expression of PDL1 are more likely to benefit from atezolizumab. There no relevant research focusing on the relationship between and clinical variables gene mutation types among NSCLC patients.MethodsNSCLC confirmed information OAK study were included in our study. Logistic regression proportional model was applied analyze risk fac...

SWI/SNF (switching/sucrose nonfermenting)-dependent chromatin remodeling establishes coordinated gene expression programs during development, yet important functional details remain to be elucidated. We show that the Brg1 (Brahma-related gene 1; Smarca4) ATPase is globally expressed at high levels during postimplantation development and its conditional ablation, beginning at gastrulation, resul...

The present study aimed to explore the underlying molecular mechanisms of hepatocellular carcinoma (HCC). RNA‑sequencing profiles GSM629264 and GSM629265, from the GSE25599 data set, were downloaded from the Gene Expression Omnibus database and processed by quality evaluation. GSM629264 and GSM629265 were from HCC and adjacent non‑cancerous tissues, respectively. TopHat software was used for al...

During the last decade, a host of epigenetic mechanisms were found to contribute to cancer and other human diseases. Several genomic studies have revealed that ∼20% of malignancies have alterations of the subunits of polymorphic BRG-/BRM-associated factor (BAF) and Polybromo-associated BAF (PBAF) complexes, making them among the most frequently mutated complexes in cancer. Recurrent mutations a...

PURPOSE Lung cancer is the worldwide leading cause of death from cancer. DNA methylation in gene promoter regions is a major mechanism of gene expression regulation that may promote tumorigenesis. However, whether clinically relevant subgroups based on DNA methylation patterns exist in lung cancer remains unclear. EXPERIMENTAL DESIGN Whole-genome DNA methylation analysis using 450K Illumina B...

Abstract Background Precision therapy for lung cancer requires comprehensive genomic analyses. Specific effects of targeted therapies have been reported in Asia populations, including Taiwanese, but studies rarely performed these populations. Method We enrolled 72 patients with non-small cell cancer, whom 61 had adenocarcinoma, 10 squamous carcinoma, and 1 combined adenocarcinoma carcinoma. Who...

The human SMARCA4 transcript has approxi-mately 5500 bp and contains an open reading frame of 4845 bp, predicting a protein of 1614 amino acid residues. There are different transcripts arising from two alternative splicing sites within intron 28 and exon 30, which predict the translation of four different BRG1 protein isoforms. In addition, between exon 26 and 27 and exon 29 and 30 there are tw...