Mutations in the human adenomatous polyposis coli (APC) gene are causative for familial adenomatous polyposis (FAP), a rare condition in which numerous colonic polyps arise during puberty and, if left untreated, lead to colon cancer. Mouse model for human FAP, Apc(Min/+) mouse, contains a truncating mutation in the Apc gene and spontaneously develops intestinal adenomas. However, the distributi...

The chilaiditi syndrome is a pathology characterized by the interposition of small or colonic intestines in space between lower surface diaphragm and liver. We report case 39-year-old man, worker, operated 3 months ago for acute appendicitis who presented with abdominal pain, urinary retention occlusive syndrome. CT scan was performed revealed bowel obstruction Chilaïditi distended loops rig...

The equine large intestine consists of the following segments (in aboral direction): the cecum, the large colon, and the small colon (Fig. 36-1). Although these segments form a continuum for the passage of digesta from the ileum to the anus, the three portions are considered to be separate structures, anatomically, functionally, and surgically. The large intestine of the horse is well developed...

Purpose: To develop modified hard gelatin capsules (MHGCs) for colon-specific delivery of hydrogel-based piroxicam microparticles.
 Methods: Solvent evaporation technique was adopted the microencapsulation using liquid paraffin (PL.MPs) and soybean oil (PS.MPs) which were subsequently encapsulated in MHGCs (water-impervious). Anti-inflammatory vitro dissolution studies conducted on unencap...

The effects of chrysotile on DNA synthesis in the gastrointestinal tract of the rat were studied by measuring the uptake of tritium-labeled thymidine; whole stomach, small intestine, colon liver were removed, cleaned, and homogenized and the DNA was isolated and assayed for tritium label.A dose-response study indicated that 2 weeks after a 5 mg/kg dose of chrysotile, DNA synthesis was increased...