نتایج جستجو برای: slp

تعداد نتایج: 1597  

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2002
Lalit Kumar Vadim Pivniouk Miguel A de la Fuente Dhafer Laouini Raif S Geha

The adapter SLP-76 is essential for thymocyte development. SLP-76(-/-) mice were reconstituted with SLP-76 deletion mutant transgenes to examine the role of SLP-76 domains in T cell development and function. The N-terminal domain deletion mutant completely failed to restore thymocyte development. Mice reconstituted with Gads-binding site and SH2 domain deletion mutants had decreased thymic cell...

Journal: :The British journal of ophthalmology 2001
R Lauande-Pimentel R A Carvalho H C Oliveira D C Gonçalves L M Silva V P Costa

AIM To evaluate the ability of structural parameters (as determined by retinal nerve fibre layer (RNFL) measurements obtained with the scanning laser polarimeter (SLP-NFA/GDx)) and functional parameters (as determined by automated perimetry) to discriminate between normal and glaucomatous eyes. METHODS In a case-control study, a total of 91 normal subjects and 94 patients with glaucoma underw...

Journal: :Investigative ophthalmology & visual science 2012
Mark J Kupersmith Randy Kardon Mary Durbin Melissa Horne Julia Shulman

PURPOSE Optical coherence tomography (OCT) shows retinal nerve fiber layer (RNFL) thickening in optic nerve head (ONH) swelling, but does not provide information on acute axonal disruption. It was hypothesized that scanning laser polarimetry (SLP) compared with OCT might reveal the status of axon integrity and visual prognosis in acute RNFL swelling. METHODS Threshold perimetry, OCT, and SLP ...

2013
Tomohiro I Yuto Nakashima Shunsuke Inenaga Hideo Bannai Masayuki Takeda

We present an algorithm for computing the Lyndon factorization of a string that is given in grammar compressed form, namely, a Straight Line Program (SLP). The algorithm runs in O(n + mnh) time and O(n) space, where m is the size of the Lyndon factorization, n is the size of the SLP, and h is the height of the derivation tree of the SLP. Since the length of the decompressed string can be expone...

Journal: :Security and Communication Networks 2016
Leron Lightfoot Yun Li Jian Ren

Wireless sensor networks (WSNs) can provide the world with a technology for real-time event monitoring. One of the primary concerns that hinder the successful deployment of WSNs is source-location privacy (SLP). The privacy of the source location is vital and highly jeopardized by the usage of wireless communications. Although message content privacy can be ensured through message encryption, i...

Journal: :The Journal of Experimental Medicine 2004
Y. Jeffrey Chiang Connie L. Sommers Martha S. Jordan Hua Gu Lawrence E. Samelson Gary A. Koretzky Richard J. Hodes

c-Cbl is an adaptor protein that negatively regulates signal transduction events involved in thymic-positive selection. To further characterize the function of c-Cbl in T cell development, we analyzed the effect of c-Cbl inactivation in mice deficient in the scaffolding molecule SLP-76. SLP-76-deficient mice show a high frequency of neonatal lethality; and in surviving mice, T cell development ...

2012
Lulu Cao Yiyuan Ding Norris Hung Kebing Yu Anna Ritz Benjamin J. Raphael Arthur R. Salomon

The SH2-domain-containing leukocyte protein of 76 kDa (SLP-76) plays a critical scaffolding role in T cell receptor (TCR) signaling. As an adaptor protein that contains multiple protein-binding domains, SLP-76 interacts with many signaling molecules and links proximal receptor stimulation to downstream effectors. The function of SLP-76 in TCR signaling has been widely studied using the Jurkat h...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2000
F A Bonilla R M Fujita V I Pivniouk A C Chan R S Geha

The SLP-76 (Src homology 2 domain-containing leukocyte protein of 76 kDa) adapter protein is expressed in T cells and myeloid cells, whereas its homologue BLNK (B cell linker protein) is expressed in B cells. SLP-76 and BLNK link immunoreceptor tyrosine-based activation motif-containing receptors to signaling molecules that include phospholipase C-gamma, mitogen-activated protein kinases, and t...

Journal: :The Journal of Experimental Medicine 2005
Jonathan S. Maltzman Lisa Kovoor James L. Clements Gary A. Koretzky

The SH2 domain containing leukocyte phosphoprotein of 76 kD (SLP-76) is critical for pre-TCR-mediated maturation to the CD4+CD8+ double positive (DP) stage in the thymus. The absolute block in SLP-76null mice at the CD4-CD8-CD44-CD25+ (double-negative 3, DN3) stage has hindered our understanding of the role of this adaptor in alphabeta TCR-mediated signal transduction in primary thymocytes and ...

Journal: :The Journal of surgical research 2004
R Prabhu K A Balasubramanian

BACKGROUND Surgical stress can lead to bacterial translocation from the intestine into systemic circulation. Adherence of bacteria onto the glycoconjugates of the brush border membrane (BBM) and surfactant coat (SLP) of the mucosal cells is the first step in the translocation of luminal bacteria. Our earlier study showed that surgical manipulation of the intestine results in oxidative stress le...

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