The skull base provides a platform for supporting the brain while serving as conduit major neurovascular structures. In addition to malignant lesions originating in base, there are many benign entities and developmental variants that may simulate disease. Therefore, basic understanding of relevant embryology is essential. Lesions centered can extend adjacent intracranial extracranial compartmen...

Objective To investigate the expression of p16, cyclin D1, retinoblastoma tumor suppressor protein (Rb) and MIB-1 in skull base chordoma and chondrosarcoma tissues, and to determine the clinicopathological significance of the above indexes in these diseases. Methods A total of 100 skull base chordoma, 30 chondrosarcoma, and 20 normal cartilage tissue samples were analyzed by immunohistochemis...