Cell migration is an integral part of re-epithelialization during skin wound healing, a complex process involving molecular controls that are still largely unknown. Here we identify a novel role for Tcf3, an essential transcription factor regulating embryonic and adult skin stem cell functions, as a key effector of epidermal wound repair. We show that Tcf3 is upregulated in skin wounds and that...

thickness skin graft to a large surgical wound in a patient with sclerodermatous skin. In this case history, the key point is a clinical one—that wound healing may be uncomplicated even if the graft is taken from affected sclerodermatous skin and transplanted to another affected area. There are reports in the literature of using artificial [8], split thickness [9] and autologous [10] skin graft...

Objective: To explore the methods for the repair of large-area limb skin avulsion wound. Method: Eleven patients with simple limb skin avulsion underwent large-area stereotypy full-thickness skin graft for wound repair. Results: Wounds were repaired very well as well as the late appearance and functions were satisfactory in all 11 patients. During follow-up, the hypertrophic scars were mild, th...

BACKGROUND Platelet rich plasma is known for its hemostatic, adhesive and healing properties in view of the multiple growth factors released from the platelets to the site of wound. The primary objective of this study was to use autologous platelet rich plasma (PRP) in wound beds for anchorage of skin grafts instead of conventional methods like sutures, staplers or glue. METHODS In a single ...

Background: Antiseptic scrub and paint can reduce bacterial colonization and postoperative wound infection. Two forms of antiseptics, povidone iodine and chlorhexidine, are commonly used in the operating theater. Objective: To study the efficacy of the reduction of bacterial colonization and surgical wound infection among these antiseptic. Material and Method: Five hundred surgical patients wer...

OBJECTIVE To study the effect of taspine hydrochloride (TA/HCl) on skin wound healing in rats and its mechanism. METHODS Bilateral round wounds were made on the backs of SD rats. The effect of TA/HCl on the skin wound was evaluated through determining closure time and contracting ability of the skin wound, observing histopathological characteristics and measuring contents of hydroxyproline (H...

North York General Hospital (NYGH), in collaboration with Nursing Practice Solutions, Smith & Nephew and the Central Community Care Access Centre, implemented a program in skin and wound care that has made best-practice, evidenced-based wound care management possible, affordable and sustainable. Focused action using advanced wound care products and proven clinical approaches has dramatically im...

introduction: in this study the effects of low power helium-neon laser radiation on the cell population of open skin full thickness wound of rats were investigated from histological and biomechanical point of views. materials and methods: 90 male rats were randomly divided into control and two experimental groups. under general anesthesia and sterile conditions around open full thickness skin w...

background and objective: angiogenesis is a complex program of several steps and it is tightly regulated by pro- and anti-angiogenic factors. angiogenesis is one of the key elements in cutaneous wound healing and skin cancers. estrogen seems to have positive modulating effect on cutaneous wound healing and this effect may be explained by its angiogenic properties. this study aims to investigate...