allergic rhinitis (ar) is an ige-mediated upper airway disease, and its impact on asthma has been widely recognized. protein tyrosine phosphatase non-receptor 22 (ptpn22) gene and the cytotoxic t-lymphocyte–associated antigen 4 (ctla-4) gene polymorphisms have been reported to be associated with several immune-related diseases. here we investigated the reffect of these two genes’ polymorphisms ...

Single-nucleotide polymorphism (SNP) mapping is the easiest and most reliable way to map genes in Caenorhabditis elegans. SNPs are extremely dense and usually have no associated phenotype, making them ideal markers for mapping. SNP mapping has three steps. First, recombinant mutant animals are generated over a polymorphic strain (usually CB4856) using standard genetic techniques. Second, the ge...

Single-Nucleotide Polymorphism of rs11061971 (+219 A>T) in Adiponectin Receptor 2 (AdipoR2) Gene and its Association with Risk Type Diabetes among Iranian Population

objective(s): accumulating evidence has demonstrated that mirnas contribute to various genetic and epigenetic modifications in the pathogenesis of gastric cancer (gc). recent studies focused on the four single nucleotide polymorphisms (snps) of pre-mirnas including rs11614913, rs3746444, rs2910164, and rs2292832. it was suggested that these four snps were significantly associated with the risk ...

conclusions in general, our study suggests that the association between lep/lepr and ghrl/ghsr with overweight/obesity and the related metabolic disturbances is inconclusive. these results may be due to unidentified gene-environment interactions. more investigations are needed to further clarify this association. results the most prevalent leptin/leptin receptor genes (lep/lepr) and ghrelin/ghr...

background: single nucleotide polymorphism (snps) are considered as one of the underlying causes of male infertility. proper sperm chromatin packaging which involves replacement of histones with protamines has profound effect on male fertility. over 20 snps have been reported for the protamine 1 and 2. materials and methods: the aim of this study was to evaluate the frequency of two previously ...

Background: Androgens have an anti-proliferative effect on endometrial cells. Human androgen receptor (AR) gene contains two polymorphic short tandem repeats of GGC and CAG, and a single-nucleotide polymorphism on exon 1 that is recognized by the restriction enzyme, StuI. Prior studies have shown that the lengths of the CAG and GGC repeats are inversely and linearly related to AR activity and a...

the growth hormone (gh) gene is a candidate for growth trait in farm animals and plays an important role in growth metabolism. growth hormone can contribute in growth metabolism when it's receptor (ghr) are on cells target. the single nucleotide polymorphism was occurred in gh and ghr genes and that associated with carcass traits in lori-bakhtiari sheep breed with using pcr-sscp. in this r...