نتایج جستجو برای: single nucleotide poly

تعداد نتایج: 1023017  

Journal: :The Journal of biological chemistry 1986
F Kishi M Maruyama Y Tanizawa A Nakazawa

A cDNA clone for muscle adenylate kinase was isolated from a cDNA library of chick skeletal muscle poly(A)+ RNA, and the DNA sequence was determined. The cDNA insert had 854 nucleotides, which consisted of the 5'-untranslated sequence of 57 nucleotides, the sequence of 582 nucleotides coding for 194 amino acids, and the 3'-untranslated sequence of 163 nucleotides and the poly(A) tail of 52 nucl...

Journal: :Acta biochimica et biophysica Sinica 2015
Yongzhong Wang Bo-Yu Xue Longgen Liu Zhen Zhu Xin Xu Hongyu Zhang Xiangke Pu Xiaoqin Liu

Poly-linker primer system for detection of single nucleotide polymorphisms and its application in genotyping hepatitis B virus Yongzhong Wang1,*,†, Bo-Yu Xue2,†, Longgen Liu2, Zhen Zhu1, Xin Xu1, Hongyu Zhang1, Xiangke Pu1, and Xiaoqin Liu1 Laboratory Centre, The Third People’s Hospital of Changzhou, Changzhou 213001, China, and University of Nanjing Traditional Chinese Medicine, Nanjing 210023...

Journal: :General physiology and biophysics 1985
F Jelen E Palecek

It has been shown earlier that the DNA double helix is opened due to a prolonged contact of the DNA molecule with the surface of the mercury electrode. At neutral pH, the opening process is relatively slow (around 100 s), and it is limited to potentials close to -1.2 V (against SCE). The opening of the double helix has been explained by strains in the DNA molecule due to strong repulsion of the...

2017

Submit Manuscript | http://medcraveonline.com Abbreviations: PCa: Prostate Carcinoma; CRPC: Castrationresistant Prostate Carcinoma; MMR: Mismatch Repair; ADT: Androgen-deprivation Therapy; OS: Overall Survival; NER: Nucleotide Excision Repair; BER: Base Excision Repair; HDR: Homology Directed Repair; HR: Homologous Recombination; DDR: DNA Damage Response; NHEJ: Non-homologous End Joining; SSB: ...

Journal: :مجله بین المللی زیست و زیست پزشکی 0
mohammed j ashour department of medical laboratory sciences, islamic university of gaza, gaza, palestine fadel a sharif department of medical laboratory sciences, islamic university of gaza, gaza, palestine

this study was conducted in order to investigate the association between the single nucleotide polymorphism (snp) rs2305957 g/a and recurrent pregnancy loss (rpl) in a group of palestinian women residing in gaza strip. a retrospective case-control study was carried out during the period of may to august 2015. a total of 380 females including 190 recurrent pregnancy loss (rpl) patients and 190 c...

Journal: :iranian journal of psychiatry 0
sadegh yoosefee neuroscience and neurology research center, qom university of medical sciences, qom, ‎iran. and department of neuroscience, school of advanced technologies in medicine, iran ‎university of medical sciences ‎‎(iums), tehran, iran‎. and health and religion research center, qom university of medical sciences, qom, iran. esmaeil shahsavand ananloo department of adult psychiatry, roozbeh hospital, school of medicine, tehran university of ‎medical sciences (tums), ‎tehran, iran. ‎and department of genomic psychiatry and behavioral genomics (dgpbg), roozbeh ‎psychiatry hospital, school of ‎medicine, tehran university of medical sciences (tums), ‎tehran, iran. mohammad-taghi joghataei department of neuroscience, school of advanced technologies in medicine, iran ‎university of medical sciences ‎‎(iums), tehran, iran‎. morteza karimipour molecular medicine group, pasteur institute of iran. mahmoudreza hadjighassem department of neuroscience and addiction studies, school of advanced technologies in medicine, tehran ‎university of medical ‎sciences (tums), tehran, iran. hoorie mohaghghegh department of neuroscience and addiction studies, school of advanced technologies in medicine, tehran ‎university of medical ‎sciences (tums), tehran, iran.

objective: although the etiology of schizophrenia is unknown, it has a significant genetic component. ‎a number of studies have indicated that neuregulin-1 (nrg1) gene may play a role in the ‎pathogenesis of schizophrenia. in this study, we examined whether the rs2439272 of nrg1 ‎is associated with schizophrenia and its negative symptoms in an iranian population.‎ method: rs2439272 was genotype...

Journal: :journal of current ophthalmology 0
رزا میری rosa miri محمدحسین حریرچیان mohammad hossein harirchian عباس تفاخری abbas tafakhori رضا شاه سیاه reza shahsiah

purpose: neuromyelitis opitca (nmo) is an autoimmune disease that relates to deposition of anti-aquaporin-4 (aqp4) igg in the central nervous system (cns). however, called seronegative nmo when patients are negative for aqp4 antibody. nevertheless, nmo is most probably an antibody mediated disease. the aim of this study was to assess the association between seronegative nmo disease and variatio...

Journal: :iranian journal of allergy, asthma and immunology 0
somayeh ahmadloo department of medical genetics, school of medicine, tehran university of medical sciences, tehran, iran. mohsen taghizadeh department of medical genetics, school of medicine, tehran university of medical sciences, tehran, iran. mohsen akhiani department of rheumatology, alborz hospital, karaj, iran. ahmad salimzadeh rheumatology research center, sina hospital, tehran university of medical sciences, tehran, iran. mohammad keramatipour department of medical genetics, school of medicine, tehran university of medical sciences, tehran, iran.

the rs2476601 (r620w, c1858t) polymorphism in ptpn22 gene has been repeatedly reported to be associated with rheumatoid arthritis (ra). the rs 2476601 is widely suggested for predictive testing and risk assessment for ra. the aim of this study was to test the possible association of this snp with ra in iranian population.a total of 872 samples (405 confirmed ra patients and 467 healthy controls...

Journal: :iranian journal of allergy, asthma and immunology 0
ahmad soltani department of cell and molecular biology, faculty of science, university of tehran, tehran, iran. sara rahmatirad department of cell and molecular biology, faculty of science, university of tehran, tehran, iran. zahra pourpak immunology, asthma and allergy research institute, tehran university of medical sciences, tehran, iran. zahra alizadeh immunology, asthma and allergy research institute, tehran university of medical sciences, tehran, iran. shiva saghafi immunology, asthma and allergy research institute, tehran university of medical sciences, tehran, iran. bashir hajibeigi tehran blood transfusion organization, tehran, iran.

mannose-binding lectin (mbl) is a ca⁺² -dependent collagenous lectin, that is produced by liver and mediates innate immune responses by opsonization of pathogens. the serum level of mbl varies widely among healthy individuals, ranging from 0.05 µg/ml (or lower) to over 5 µg/ml, mainly depending on genetic variation. this study has examined promoter and exon 1 of mbl2 genotype among 117 iranian ...

Journal: :BioTechniques 2003
In-Taek Hwang Yun-Jee Kim Seung-Hyun Kim Chae-Il Kwak Young-Yun Gu Jong-Yoon Chun

A novel primer designed to improve the specificity of PCR amplification, called the annealing control primer (ACP), comprises a tripartite structure with a polydeoxyinosine [poly(dI)] linker between the 3' end target core sequence and the 5' end nontarget universal sequence. We show that this ACP linker prevents annealing of the 5' end nontarget sequence to the template and facilitates primer h...

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