Parkinson’s disease (PD) is characterized by progressive dopaminergic neuron loss or dysfunction and the second most prevalent neurodegenerative disorder after Alzheimer’s disease. However, current therapeutic strategies for PD are limited to treating outcomes of this rather than preventing it. Sinapic acid (SA) a phenolic compound with potential antioxidant properties, which reportedly acts as...

Abstract Curcuma longa is an important dietary plant which possess several pharmacological activities, including antioxidant, antimicrobial, anti-inflamatory, anticancer and anti clotting etc. The aim of the present study was to determine phenolic profile in vitro antioxidant antidiabetic activities. In HPLC chromatogram rhizome extract 15 compounds were identified namely Digalloyl-hexoside, Ca...

This study was conducted to determine the phenolic compounds that may be utilized as chemotaxonomic identify some concentration are useful for pharmaceutical purposes from 5 taxa belongs Brassicaceae family which are; Cardaria draba (L.) Desv., Lepidum aucheri Boiss., Sisymbrium irio L., officinale Scop., and septulatum DC. Leaves powder of these were collected analyzed by High-performance liqu...

Pharmacognosy Research,2021,13,4,218-226.DOI:10.5530/pres.13.4.14Published:October 2021Type:Original ArticleAuthors:Bonface Mwamatope, David Tembo, Elizabeth Kampira, Cecilia Maliwichi-Nyirenda, and Victoria Ndolo Author(s) affiliations:Bonface Mwamatope1, Tembo2,*, Kampira3, Maliwichi-Nyirenda4, Ndolo5 1Biomedical Sciences Department, College of Medicine, University Malawi, Blantyre, MALAWI. 2...

Spectrophotometric methods for the determination of total polyphenols and flavonoids are often used because they simple, sensitive, precise. Before using these methods, must be validated to ensure quality obtained data prove that method is suitable its purpose. The aim this study was validate spectrophotometric flavonoids. has been according polyphenol standards, which belong groups phenolic ac...

Untargeted metabolomics identified urinary biomarkers able to discriminate between the intake of fresh hand-squeezed and industrially processed orange juices. Processing led an upregulation in excretion hydroxy-polymethoxyflavone sulfates, abscisic acid, sinapic acid 4′-glucuronide. The demethylated polymethoxyflavone metabolites were produced with a significant interindividual variability sugg...

To reveal the structural principles determining substrate specificity of 4-coumarate:CoA ligase (4CL), the crystal structure of the phenylalanine activation domain of gramicidin S synthetase was used as a template for homology modeling. According to our model, 12 amino acid residues lining the Arabidopsis 4CL isoform 2 (At4CL2) substrate binding pocket (SBP) function as a signature motif genera...