epilepsy is a neurological disease of the central nervous system. it is estimated that about 50-70 million people worldwide suffer from this chronic disorder and 20 to 30% are resistant to conventional anti-epileptic drugs. in the epilepsy therapeutic arena, there is real need for developing novel antiepileptogenesis treatments that offer a way to prevent the onset or the progression of the dis...

biotin is a water-soluble vitamin and co-factor for activation of carboxylases apoenzymes. biotinidase enzyme is essential for release of biotin from apoenzymes. absence of biotinidase is an autosomal recessive trait with a prevalence of 1 in 60000. clinical manifestations of biotinidase deficiency include dermatitis, alopecia, seizures, hypotonia, developmental delay, hearing loss, visual impa...

background: patients with gastroesophageal reflux disease (gerd) unresponsive to proton pump inhibitor (ppi) therapy are often labeled as having refractory gerd. one of the probable etiologies of refractory gerd is delayed gastric emptying. refractory gerd associated with gastroparesis is a complex condition with no definitive treatment to date. we opted, for the first time, to test the hypothe...

treatment of severe immune thrombocytopenic purpura (itp) accompanied by life-threatening bleeding events is challenging and a combination of treatment measures should be undertaken to rapidly increase the platelet count. herein, we report a case of severe itp in a seven-year-old boy who suffered from massive bleeding which was totally unresponsive to conventional therapeutic interventions. sin...

Hyperbranched polyimide–silica hybrids (HBPI–silica HBDs) and hyperbranched polyimide–silica composites (HBPI–silica CPTs) were prepared, and their general and gas transport properties were investigated to clarify the effect of silica sources and preparation methods. HBPI–silica HBDs and HBPI–silica CPTs were synthesized by two-step polymerization of A2 + B3 monomer system via polyamic acid as ...

background: the induction chemotherapy regimen for acute myeloid leukemia has evolved as once induction is completed patients progress through the consolidation phase and achieve remission in 76% of cases. for patients with relapsed or refractory disease, alternative chemotherapy agents are available. monoclonal antibody therapy with biological agents, such as the immunotoxin gemtuzumab ozogami...

objective: the aim of this study was to evaluate the effect of premenstrual syndrome (pms) treatment with selective serotonin reuptake inhibitor (ssri) on treatment response of refractory hypertension of the patients. method: this was a triple-blind randomized clinical trial conducted on female patients suffering from refractory hypertension and pms at the same time. we obtained informed consen...

purpose: to determine the outcomes of visual correction with femto-lasik following pk. methods: in this prospective study, 34 eyes of 31 patient who had undergone thin – flap lasik due to high refractive error after corneal grafting were evaluated .after complete ocular examination and assessment of uncorrected and corrected distant visual acuity (ucva and bcva) , the patients underwent femto-l...

Silica scaling potential from geothermal waters puts limits on to what extent the heat from the water can be extracted. Once the waters become over-saturated with respect to amorphous silica, the handling of such waters becomes problematic. Many methods have been proposed to address this problem. One of them is aging the geothermal waste water allowing monomeric silica in excess of amorphous si...