In this study various abnormal haemoglobin fractions on HPLC were observed in 158 cases out of the total 300 screened paediatric anaemic cases. Of the 300 paediatric cases, samples analyzed on CE-HPLC for haemoglobinopathies, maximum 67 (22.33%) cases were diagnosed as S-β double heterozygous, 39(13%) as sickle cell trait, 27 (9 %) as β-thalassaemia major, 10 (3.33 %) as sickle cell disease, 05...

Sickle cell trait is considered as a benign condition as these individuals carry only one defective gene and typically have their life span similar to the normal population without any health problems related to sickle cell. Only under extreme conditions, red cells become sickled and can cause clinical complications including hematuria and splenic infarction. Although twofold increased risk of ...

Haematuria is a well-known complication of sickle cell disease. A South African coloured patient with repeated episodes of gross haematuria is described in whom the diagnosis of sickle cell disease was suggested after the finding of sickled erythrocytes in the urine sediment. The diagnosis was then confirmed by haemoglobin electrophoresis, which revealed sickle cell trait (Hb-AS). It is conclud...