BACKGROUND Some reports have shown that co-inheritance of α-thalassemia and sickle cell disease improves hematological parameters and results in a relatively mild clinical picture for patients; however, the exact molecular basis and clinical significance of the interaction between α-thalassemia and sickle cell disease in India has not yet been described. There is little agreement on the clinica...

INTRODUCTION Parvovirus B19 is a cause of hemolysis and red blood cell aplasia in patients with sickle cell anemia. The present study aimed to assess parvovirus B19 infection among sickle cell anemia patients. METHODOLOGY All patients (n = 138) included in the study were sickle cell anemia patients. Blood donors were used as a control group. Assessment of parvovirus B19 antibodies and viral D...

Sickle cell anemia is a genetic disease that primarily affects the black population. This anemia is due to a homozygous state of the abnormal hemoglobin S. An alteration occurs on the DNA molecule involving the substitution of the amino acid valine for glutamic acid at the sixth position on the beta polypeptide chain. This biochemical variation on the DNA molecule creates a physiological change...

OBJECTIVE To correlate spleen function with soluble transferrin receptor (sTfR) levels and red cell ferritin (RCF) values in patients with sickle cell diseases. DESIGN Prospective study. LOCATION University Hospital, School of Medical Sciences, State University of Campinas; a tertiary hospital. PARTICIPANTS 60 patients with sickle cell diseases, in a steady state, who had not received blo...

B11 l ;:OUlCHI B.. ‘TANAKA, GEO1 IE 0. CLIFF0III AND AluNoLm II. AXELItOI) S INCE the advemit of the newer t.echmiics for differentiatimig hemoglobimi types,’4 mio (‘ase of sickle cell anemia (homozygous 5) proven by these miiethods has I)eemi described imi which aseptic necrosis of the femnoral head was present. Aseptic miecrosis of the femnoral capital epiphysis has beemi reported by Smit.h a...

Background Drugs used by patients with sickle cell anemia to relieve pain have side effects, so the use of non-pharmacological palliative methods (such as massage, muscle relaxation, heat, drinking fluids, etc.) can be considered. We aimed to determine effect of non-pharmacological palliative methods training among adolescents with sickle cell anemia. <stro...

background: molecular genetic factors regulating hemoglobin f (hb f) expression are important modifiers of the severity of sickle cell anemia (ss).   methods: the prevalence of xmni polymorphic site, the g g: a g ratio and the hb f level were determined using pcr-rflp procedure, hplc and alkaline denaturation method, respectively, in various haplotypes of 52 patients with ss, 18 patients with s...

Previous studies have determined the short-term toxicity profile, laboratory changes, and clinical efficacy associated with hydroxyurea (HU) therapy in adults with sickle cell anemia. The safety and efficacy of this agent in pediatric patients with sickle cell anemia has not been determined. Children with sickle cell anemia, age 5 to 15 years, were eligible for this multicenter Phase I/II trial...

BACKGROUND AND OBJECTIVES Adhesion molecules on the surface of erythrocytes, leukocytes and platelets are involved in vascular occlusion in sickle cell anemia. Hydroxyurea treatment of sickle cell anemia patients leads to clinical improvement and reduces the incidence of vaso-occlusive episodes. It has been previously demonstrated that hydroxyurea treatment also reduces the expression of adhesi...