Background Although dry mouth is a common symptom in systemic sclerosis (SSc), there lack of studies evaluating the salivary glands this heterogenous disease. Objectives To study ultrasonographic changes patients with and to correlate these disease activity markers, clinical data autoantibodies. Methods Forty-seven SSc forty-three healthy age sex matched controls were studied. Duration illness,...

OBJECTIVE There is no established disease-modifying treatment of xerostomia and xerophthalmia in SS. This retrospective study was performed in order to evaluate the efficacy of HCQ for glandular function, i.e. saliva and tear production. METHODS Fourteen patients with primary SS (pSS) were included (Group A). All patients were anti-Ro and/or -La antibody positive except one. Patients were tre...

Background: Primary SjÖgren´s Syndrome (PSS) is an autoimmune disease characterized by sicca symptoms, autoantibodies and lymphocytic infiltrate in exocrine glands. Classification diagnosis of PSS performed applying 2002 AECG, 2012 ACR or 2016 ACR-EULAR criteria. Time evolution symptoms has been associated with different clinical, serological pathology findings. Objectives: Document profiles co...

Sjögren’s syndrome (SS) is a chronic autoimmune disease associated with the production of autoantibodies and characterized by a progressive lymphocytic and plasma cell infiltration of the salivary and lacrimal glands leading to xerostomia and keratoconjunctivitis sicca (1). A Danish ophthalmologist named Henrik Sjögren in 1932 was the first one, who reported the triad of keratoconjunctivitis si...

Sjögren's Syndrome (SS) is a chronic inflammatory disorder characterized by diminished lacrimal and salivary gland function. SS occurs in primary form not associated with other disease secondary that complicates rheumatic conditions. The most common rheumatoid arthritis. In or SS, decreased exocrine function leads to the sicca complex, condition of dry eyes (keratoconjunctivitis sicca) mouth (x...

Secondary sicca syndrome has been described in silicotic and exposed nonpneumoconiotic individuals. Systemic autoimmune pathogenic mechanisms have been thought to be responsible. Salivary gland mineral deposition has not so far been implicated. We describe the case of a dental technician who sand-blasted dental prostheses and developed silicoproteinosis and sicca syndrome. Immunological studies...

The Sjögren syndrome has been diagnosed in patients with HTLV-1 associated myelopathy and dry mouth and dry eyes are documented in HTLV-1 carriers. However the diagnosis of Sjögren syndrome in these subjects has been contested. In this cross-sectional study, we evaluated the role of immunological factors and proviral load, in sicca syndrome associated with HTLV-1 in patients without myelopathy....

Viridin B, a bacteriocin produced by Streptococcus mitis (mitior), is bactericidal to Neisseria sicca. Oxygen consumption by actively growing N. sicca cultures ceased immediately upon exposure to viridin B. Adenosine triphosphate production was slightly enhanced within 1 h of exposure to the bacteriocin but was subsequently repressed. The uptake and incorporation of glucose was prevented in the...