In this paper we describe the distribution problems faced by one of the largest retailers in the distribution and sale of fast moving consumer goods in the U.K. The paper describes an initial solution method, which is then improved by a novel form of simulated annealing. A computational experiment for the improvement algorithm has been also carried out in order to illustrate the flexibility of ...

Consumer goods companies must reinvent their digital marketing capabilities to actively engage consumers and move them along the path to purchase by consistently delivering highly personalized, authentic and valuable brand experiences across marketing channels.

Voltage-gated conductances on dendrites of layer 5 pyramidal neurons participate in synaptic integration and output generation. We investigated the properties and the distribution of large-conductance calcium-activated potassium channels (BK channels) in this cell type using excised patches in acute slice preparations of rat somatosensory cortex. BK channels were characterized by their large co...

Mutations in the leucine-rich repeat kinase 2 (LRRK2) have been associated with familial and sporadic cases of Parkinson disease. Mutant LRRK2 causes in vitro and in vivo neurite shortening, mediated in part by autophagy, and a parkinsonian phenotype in transgenic mice; however, the underlying mechanisms remain unclear. Because mitochondrial content/function is essential for dendritic morphogen...

BACKGROUND Most antiepileptic drugs (AEDs) inhibit seizure generation by acting on voltage-dependent ion channels. Voltage-dependent sodium and calcium channels are commonly expressed in brain and heart, suggesting that AEDs may have considerable cardiodepressive effects, thereby facilitating sudden cardiac death as a potential cause of sudden unexpected death in epilepsy. Here, we investigated...

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Selling products through an intermediary has always been advantageous for the manufacturer of goods or service providers. This becomes more relevant when you are selling services and particularly a financial service. The insurance is in ambit services. Therefore, relevance channels increased to highest, because product subject persuasion, so personal contact increase market efficiency become re...

This paper proposes an analytical framework to examine the market and welfare impacts of GMOs, when some consumers refuse genetically modified organisms (GMOs) and when two supply channels are segregated (one for goods that containing GMOs and one for non-genetically-modified identity-preserved goods). Our analytical framework begins at the level of individual farmers, handlers and consumers, t...