Severe asthma in children is a complicated and heterogeneous disorder that is extremely challenging to treat. Although most children with asthma derive clinical benefit from daily administration of low-to-medium-dose inhaled corticosteroid (ICS) therapy, a small subset of children with "severe" or "refractory" asthma require high doses of ICS and even systemic corticosteroids to maintain sympto...

Asthma is a complex chronic inflammatory disease of multifactorial etiology. International guidelines increasingly recognize that a standard "one size fits all" approach is no longer an effective approach to achieve optimal treatment outcomes, and a number of disease phenotypes have been proposed for asthma, which has the potential to guide treatment decisions. Among the many asthma phenotypes,...

background: asthma is a multifactorial disease and its severity varies with the inflammatory grade. there are conflicting reports about the roles of trace elements in asthma. this study examined the effects of zinc (zn), copper (cu), and selenium (se) concentrations in sera of patients with allergic asthma attending ghaem hospital, mashhad, iran. methods: forty-nine patients, aged 10 to 50 year...

asthma is a global problem that affects over 300 million people in the world. the main reason of asthma is allergy and atopy. asthmatic patients are sensitized to allergens that can be resulting asthma attacks. fungi as an allergen can be sensitized atopic people and present a severe asthma. fungi have been found in water-damaged homes of asthmatic patients. allergic asthma is associated with e...

The prevalence of asthma is approximately 5% to 10% in the general population. Of these, approximately 5% to 10% are severe asthmatics who respond poorly to asthmatic drugs, including high-dose inhaled steroids. Severe asthmatics have persistent symptoms, frequent symptom exacerbation, and severe airway obstruction even when taking high-dose inhaled steroids. The medical costs of treating sever...

OBJECTIVE To estimate the distribution of asthma severity in a population-based sample of children from Salvador, Brazil. METHODS An epidemiologically oriented questionnaire (International Study of Asthma and Allergies in Childhood, ISAAC) and a questionnaire based on criteria used in clinical practice (The Global Initiative for Asthma, GINA) were administered simultaneously to 417 children a...

STUDY OBJECTIVES (1) To assess the prevalence of specific factors considered causative or contributive to asthma in a population of patients seen in a specialized asthma clinic, and to determine whether any of these factors were associated with more severe disease; and (2) to assess the utilization of inhaled steroids by asthma severity in this population and compare it with published guideline...

Allergic asthma is the most common acute inflammatory airway disorder and their incidence population has exploded in the last years, being estimated that over 300 million people worldwide have the condition. Here, we present a brief overview of relationship of allergic asthma with diet and food intake. Several studies have shown that most asthma cases are due to an allergic immune response to e...

OBJECTIVE To determine the prevalence of systemic corticosteroid-induced morbidity in severe asthma. DESIGN Cross-sectional observational study. SETTING The primary care Optimum Patient Care Research Database and the British Thoracic Society Difficult Asthma Registry. PARTICIPANTS Optimum Patient Care Research Database (7195 subjects in three age- and gender-matched groups)-severe asthma ...

Background Patients with severe asthma represent a significant unmet clinical need, however the evidence base for the management of these patients is small. Published literature on prevalence of severe asthma is quite heterogeneous and we do not have accurate data in Hungary. In 2010 we started to build up a severe asthma database involving patients who were treated in the pulmonary care networ...