Many neurological conditions are caused by immensely heterogeneous gene mutations. The diagnostic process is often long and complex with most patients undergoing multiple invasive and costly investigations without ever reaching a conclusive molecular diagnosis. The advent of massively parallel, next-generation sequencing promises to revolutionize genetic testing and shorten the 'diagnostic odys...

of essential material Set theory For your reference we collect some facts on set theory. We always look at a base setX and subsets thereof. Here are some precise definition: • A ⊆ X is a subset of X if x ∈ A implies x ∈ X. The collection of all subsets of X is called the power set of X. We denote the power set of X by (X). • If A,B ⊆ X we write A ⊆ B if x ∈ B for every x ∈ A and A = B if A ⊆ B...

objective(s): the aim of this study was to investigate the methylation status and mrna expression levels of p15, death-associated protein kinase (dapk), and suppressor of cytokine signaling-1 (socs1) genes in multiple myeloma (mm). materials and methods: the bone marrow samples of 54 mm patients were collected and the methylation status of the p15, dapk, and socs1 gene promoter regions was dete...

conclusions some results of the correlation coefficients are not the same with visualization. the reason may be due to the small number of data. materials and methods in the foundation-application study, we constructed two-way gene networks using nonparametric methods, such as spearman’s rank correlation coefficient and blomqvist’s measure, and compared them with pearson’s correlation coefficie...

Addendum to: Becherel OJ, Yeo AJ, Stellati A, Heng EYH, Luff J, Suraweera AM, et al. Senataxin plays an essential role with DNA damage response proteins in meiotic recombination and gene silencing. PLoS Genet 2013; 9:e1003435; PMID:23593030; http://dx.doi.org/10.1371/journal. pgen.1003435.

Let X and A be sets and α : X → A a map between them. We call a map μ : X ×X ×X → A an approximate Mal’tsev operation with approximation α, if it satisfies μ(x, y, y) = α(x) = μ(y, y, x) for all x, y ∈ X. Note that if A = X and the approximation α is an identity map, then μ becomes an ordinary Mal’tsev operation. We prove the following two characterization theorems: a category X is a Mal’tsev c...