Topical preparations of Anemopsis californica have been used by Native American tribes in the southwestern United States and northern Mexico to treat inflammation and infections. We report results of bioassay-guided isolation conducted on a sample of A. californica roots. The furofuran lignans sesamin (1) and asarinin (2) were isolated and shown to have MIC values ranging from 23 to 395 µM agai...

Several studies have demonstrated a link between blood viscosity and various forms of liver dysfunction. Therefore, we investigated the effect of liver protective herbal materials, Sesamin combined with extract of Schisandra chinensis berry (Schisandra) for its potential to improve blood fluidity in humans. Ten human subjects were recruited to study the effect of sesamin combined with schisandr...

The aim of the present study was to evaluate in vitro effects of dietary phytochemicals naringenin, quercetin, and sesamin on the activities of ethoxy- (EROD; CYP1A) and benzyloxy- (BROD; CYP3A) resorufin O-dealkylases after the exposure to the cocktail of persistent organic pollutants (POPs). CD-1 mice were exposed from weaning, through gestation and lactation to a defined mixture of POPs. Hep...

genic medicine, and it has been used as a crude drug to treat stress-induced physiological changes, various allergic conditions, inflammation and cancer. An aqueous extract of the stem bark of A. senticosus HARMS (ASH) from Japan and its components, chlorogenic acid (CHA) and syringaresinol di-o-b-D-glucoside (SYG), markedly prevent the ulcerogenesis in rats subjected to restraint stress in wat...

A rapid, sensitive and selective liquid chromatography-tandem mass spectrometry was developed to determine two epimeric furofuran lignans (sesamin and asarinin) simultaneously from Asarum heterotropoides extract in rat plasma. Simple protein precipitation with acetonitrile was performed to extract analytes by using alantolactone as an internal standard. Chromatographic separation was achieved u...

The major issue of the current era is an unbalanced and poor diet like unhealthy fast foods, main cause various diseases. Most nutraceutical pharma industries formulating medicines from artificial sources are expensive have several side effects. However, scientists making efforts to find out natural for betterment human health treatment Simultaneously, worldwide preferences shifted resources un...