I read with interest the recent article by Wilson et al (2003). On the basis of a randomised, double-blind placebo-controlled trial, they conclude that sertraline is not effective in preventing recurrent episodes of depression. However, I would like to make certain observations. First, looking at Table 2 (p. 494), we find that the number of patients remaining in the study at 100-week follow-up ...

BACKGROUND Interventions including physical exercise may help improve the outcomes of late-life major depression, but few studies are available. AIMS To investigate whether augmenting sertraline therapy with physical exercise leads to better outcomes of late-life major depression. METHOD Primary care patients (465 years) with major depression were randomised to 24 weeks of higher-intensity,...

BACKGROUND Despite significant advancements in psychopharmacology, treating major depressive disorder (MDD) is still a challenge considering the efficacy, tolerability, safety, and economical costs of most antidepressant drugs. One approach that has been increasingly investigated is modulation of cortical activity with tools of non-invasive brain stimulation - such as transcranial magnetic stim...

I read with interest the recent article by Wilson et al (2003). On the basis of a randomised, double-blind placebo-controlled trial, they conclude that sertraline is not effective in preventing recurrent episodes of depression. However, I would like to make certain observations. First, looking at Table 2 (p. 494), we find that the number of patients remaining in the study at 100-week follow-up ...

one of the challenges in the management of primary monosymptomatic enuresis (pme), especially in adolescents, is response failure to medical regimens such as desmopressin. this prospective study aimed at addressing the efficacy of sertraline in the treatment of 25 adolescents (13-18 year old) with pme having experienced failure to previous desmopressin therapy. patients were recommended to take...

BACKGROUND Anxiety disorders are common psychiatric conditions affecting children and adolescents. Although cognitive behavioral therapy and selective serotonin-reuptake inhibitors have shown efficacy in treating these disorders, little is known about their relative or combined efficacy. METHODS In this randomized, controlled trial, we assigned 488 children between the ages of 7 and 17 years ...

Background. Although uremic pruritus is a common and upsetting problem of chronic kidney disease, there is no approved treatment for it. This study was undertaken to find the efficiency of sertraline as a possible treatment for uremic pruritus. Methods. 19 ESRD patients under hemodialysis with severe chronic pruritus were randomly selected to participate in this before-after clinical trial. Bef...

OBJECTIVE To compare the effectiveness of group cognitive-behavioral therapy (GCBT) and of sertraline in treatment-naïve children and adolescents with obsessive-compulsive disorder. METHOD Between 2000 and 2002, 40 subjects between 9 and 17 years old were randomized to receive GCBT (n = 20) or sertraline (n = 20). GCBT consisted of a manual-based 12-week cognitive-behavioral protocol adapted ...

OBJECTIVE To construct a cost-utility model comparing escitalopram with sertraline in the treatment of major depressive disorders. METHODS A decision analytic model was created to compare the cost-utility of these two antidepressants from the perspective of a managed-care organization. The model was designed to compare 10-20 mg/day of escitalopram to 50-200 mg/day of sertraline. Benefits (uti...

Introduction: Depression is the most prevalent psychological problem among hemodialysis (HD) patients. Inflammatory factors have been reported to play an important role in the pathogenesis of depression. The association between depression and inflammatory factors was established in chronic kidney disease (CKD) patients. Sertraline, a selective serotonin reuptake inhibitor (SSRI) antidepressant,...