The main factor that affects the prognosis of patients with head and neck cancer (HNC) is regional lymph node metastases. For this reason, the accurate evaluation of neck metastases is required for neck management. This study investigates the sentinel lymph node identification and the accuracy of the histopathology of the sentinel lymph node in patients with HNC. Eleven patients with histologic...

INTRODUCTION The purpose of this study was to identify tumor characteristics of primary malignant melanoma predictive of sentinel lymph node positive status, and then to determine whether sentinel lymph node status has an impact on recurrence and survival. MATERIAL AND METHODS A total of 100 patients with primary malignant skin melanoma were analyzed. The prospective melanoma database identif...

OBJECTIVE Sentinel lymph node frozen section is used to obviate the need for a second operation in breast cancer patients with involved nodes. However, the overall sensitivity, specificity and accuracy of sentinel lymph node frozen section are debated, and the impact of sentinel lymph node frozen section positivity on the risk of additional nodal metastases is not known and was the focus of thi...

background: the impact of positive intramammary lymph node (im ln) on the prognosis of patients with breast cancer has been debated for years; likewise, the standard management of patients with positive im ln remains unclear, especially when it is identified by preoperative imaging or by sentinel lymph node biopsy. the present study aims at reviewing the level of concurrent involvement of im ln...

INTRODUCTION The objective of this study is to analyze our experience in the use of sentinel node biopsy (SNB) in melanoma and identify the predictive factors of positive SNB and multiple drainage. MATERIAL AND METHODS Retrospective study of patients who underwent SNB for melanoma between August of 2000 and February of 2013. RESULTS SNB was performed in 125 patients with a median of age of ...

BACKGROUND We investigated the presence and distribution of the sentinel and the non-sentinel node micrometastases using complete serial sectioning and immunohistochemical staining (IHC), to inspect whether lymph node micrometastases spread to the sentinel lymph nodes first. METHODS A total of 35 patients, who underwent gastrectomy with a sentinel lymph node biopsy for gastric cancer, were en...

INTRODUCTION A controversial aspect of breast cancer management is the use of sentinel lymph node biopsy (SLNB) in patients requiring neoadjuvant chemotherapy (NCT). This paper discusses the detection rate (DT) and false negatives (FN) of SLNB after NCT to investigate the influence of initial nodal disease and the protocols applied. METHODS Prospective observational multicenter study in women...

Background: Sentinel node biopsy (SLNB) is the standard of care for breast cancer treatment and it is getting wide acceptance in Iran. The radiation safety of the procedure has been investigated under controlled conditions, but the standard dose of radiotracer and techniques are not always observed in the community setting. The aim of this study was to assess the magnitude of the absor...

BACKGROUND The optimum timing of sentinel-lymph-node biopsy for breast cancer patients treated with neoadjuvant chemotherapy is uncertain. The SENTINA (SENTinel NeoAdjuvant) study was designed to evaluate a specific algorithm for timing of a standardised sentinel-lymph-node biopsy procedure in patients who undergo neoadjuvant chemotherapy. METHODS SENTINA is a four-arm, prospective, multicent...

List of Papers This thesis is based on the following papers, which are referred to in the text by their Roman numerals. Serial sectioning of breast cancer sentinel nodes does not significantly improve false negativity rate. Manuscript. on behalf of the Swedish Breast Cancer Group and the Swedish Society of Breast Surgeons. Axillary recurrence rate 5 years after negative sentinel node biopsy for...