Combination chemotherapy forms the backbone of cancer treatment. There is a need for new drug combinations for the treatment of mantle cell lymphoma (MCL). Herein, we show that gallium maltolate, a novel gallium compound, synergizes with bortezomib, a proteasome inhibitor, to induce cell death in MCL Granta cells. Cells exposed to either agent displayed caspase-3 activation, a loss of mitochond...

Articles you may be interested in A thermalization energy analysis of the threshold voltage shift in amorphous indium gallium zinc oxide thin film transistors under simultaneous negative gate bias and illumination Instability of amorphous hafnium-indium-zinc-oxide thin film transistors under negative-bias-illumination stress Appl. Investigation of zinc interstitial ions as the origin of anomalo...

The reasons why aminoglycosides are bactericidal have not been not fully elucidated, and evidence indicates that the cidal effects are at least partly dependent on iron. We demonstrate that availability of iron markedly affects the susceptibility of the facultative intracellular bacterium Francisella tularensis strain SCHU S4 to the aminoglycoside gentamicin. Specifically, the intracellular dep...

A series of molecular gallium compounds were analyzed using X-ray photoelectron spectroscopy (XPS). Specifically, the Ga 2p3/2 and Ga 3d5/2 photoelectron binding energies and the Ga L3M45M45 Auger electron kinetic energies of compounds with gallium in a range of assigned oxidation numbers and with different stabilizing ligands were measured. Auger parameters were calculated and used to generate...

The melting point of gallium (29.7646 °C) is a defining thermometric fixed point of the International Temperature Scale of 1990 (ITS-90). Realization of this melting point is performed using a fixedpoint cell containing high-purity (≥99.999 99 wt. % pure) gallium. A 30 kg single lot of gallium (99.999 9956 wt. % pure) constituting Standard Reference Material (SRM) 1751 was evaluated, and certif...

Received 10/21/2000; revised 11/14/2000; accepted 11/21/2000 For correspondence or reprints contact: Dong-Ling You, M.D., Department of Nuclear Medicine, Sun Yat-Sen Cancer Center, 125, Lih-Der Road, Pei-Tou District, Taipei, Taiwan. Tel: (886)2-28970011 ext. 1110, Fax: (886)2-28971100, E-mail: [email protected] Granulocytic sarcoma is an extramedullary tumor of myeloproliferative precurso...

Gallium 67 citrate was evaluated with conventional scanning and emission computed tomography (CT) scanning as a method of pretreatment staging of the intrathoracic, especially mediastinal, spread of lung cancer. Of 31 patients with tumours of various histological types, the isotope was concentrated in the primary lesion in all but one. In 10 out of 12 patients who underwent surgical exploration...

Chromium-doped gallium sesquiselenide, Cr:Ga2Se3, is a member of a new class of dilute magnetic semiconductor exploiting intrinsic vacancies in the host material. The correlation among room-temperature ferromagnetism, surface morphology, electronic structure, chromium concentration and local chemical and structural environments in Cr:Ga2Se3 films grown epitaxially on silicon is investigated wit...

The bulk nucleation and basal growth of semiconducting nanowires from molten Ga pools has been demonstrated earlier using oxygen/hydrogen plasma over molten Ga pools. Herein, we extend the above concept for bulk synthesis of oxide and sulfide nanowires of low-melting metal melts such as Sn and In. Specifically, nanowires of b-Ga2O3, b-In2O3, SnO2, a-Ga2S3, and b-In2S3 were synthesized using dir...

Lamellar nanocomposites based on semiconducting polymers incorporated into layered inorganic matrices are prepared by the co-assembly of organic and inorganic precursors. Semiconducting polymer-incorporated silica is prepared by introducing the semiconducting polymers into a tetrahydrofuran (THF)/water homogeneous sol solution containing silica precursor species and a surface-active agent. Semi...