A series of selenium analogs of physiologically active thiopurines and thiopyrimidines has recent ly been prepared (9). The well established antitumor activity of some of the analogous mercapto compounds, particularly 6-mercaptopurine, which has enjoyed wide clinical use in the treatment of various types of leukemia (3,12), indicated the desirability of comparing the chemical and biologi cal pr...

Organometallic compounds are widely used in almost all sectors of industry. as a result of emissions from natural and anthropogenic sources they are released to the environment, where they undergo a variety of conversions and interactions. some organometallic compounds exhibit high toxicity. organometallic compounds of mercury, tin, lead, selenium and arsenic are among the most common and hazar...

The importance of selenium for organisms can be explained by its existence as selenocysteine in the catalytic centers of glutathione peroxidase and thioredoxin reductase. Another selenoamino acid, selenomethionine, is the major form of selenium in foods, and organisms that require selenium as a nutrient directly metabolize selenomethionine to a reactive form of selenium or store it in general p...

Selenium is an essential trace element for humans and other animals, and there is mounting evidence for the efficacy of certain forms of selenium as cancer-chemopreventive compounds. However, over the years, numerous elements such as As, Cu, Zn, Cd, Hg, Sn, Pb, Ni, Co, Sb, Bi, Ag, Au, and Mo have been found to inhibit anti-carcinogenic effects of selenium, which may affect the anti-carcinogenic...

Selenium (Se) and many of its compounds are among the most toxic micronutrients. Therefore, determining the optimal level of selenium in the diet of fish is one of the main concerns of researchers. The present study was designed to investigate the effects of Sel-Plex® (Selenium-enriched Saccharomyces cerevisiae yeast) on blood biochemical parameters in juvenile Siberian sturgeon, Acipenser baer...

Background: Critical macromolecules of cells such as DNA are in exposure to damage of free radicals that induced from the interaction of ionizing radiation with biological systems. Selenium and vitamin-E are natural compounds that have been shown to be a direct free radical scavenger. The aim of this study was to investigate the radioprotective effect of selenium and vitamin-E separately and sy...