Background Selective serotonin reuptake inhibitors (SSRIs) and serotonin and noradrenaline reuptake inhibitors (SNRIs) have been commonly prescribed for depression treatment. However, their effects on blood pressure are unclear. Materials and methods Effects on blood pressure of depressive patients in two groups (SSRIs versus placebo and SSRIs versus SNRIs) were evaluated. A search was conduc...

Circadian rhythm abnormalities, as shown by sleep/wake cycle disturbances, constitute one the most prevalent signs of depressive illness, advances or delays in the circadian phase, or changes in rhythms' amplitude, being documented in patients with major depressive disorder (MDD), seasonal affective disorder or bipolar disorder. The disturbances in the amplitude and rhythm of melatonin secretio...

BACKGROUND Although several studies show that there is an increased risk of bleeding events during antidepressant treatment with selective serotonin reuptake inhibitors (SSRIs), few studies show direct effects in vitro of SSRIs on hemostasis. METHODS This study was undertaken to investigate the effects on platelet adhesion and plasma coagulation (APTT and PT) of two common SSRIs, citalopram a...

Background: Although several studies show that there is an increased risk of bleeding events during antidepressant treatment with selective serotonin reuptake inhibitors (SSRIs), few studies show direct effects in vitro of SSRIs on hemostasis. Methods: This study was undertaken to investigate the effects on platelet adhesion and plasma coagulation (APTT and PT) of two common SSRIs, citalopram a...

various studies suggest that selective serotonin reuptake inhibitors (ssris) may be useful in treating pathological skin picking (psp). this study sought to assess effectiveness of citalopram in comparison with placebo in treating psp. forty five individuals with psp were recruited in a four-week, randomized clinical trial of citalopram (20 mg/day) in comparison with placebo. study measures ass...

Abstract Background Major depressive disorder (MDD), common mental disorder, lacks objective diagnostic and prognosis biomarkers. The of this study was to perform proteomic analysis identify proteins with changed expression levels after antidepressant treatment investigate differences in protein between MDD patients healthy individuals. Methods A total 111 obtained from literature review were s...

The aim of the present study was to investigate the influence of antidepressants with different chemical structures and mechanisms of action affecting serotonergic and/or noradrenergic systems - tricyclic antidepressant drugs (TAD), selective serotonin reuptake inhibitors (SSRIs) and novel antidepressants (mirtazapine, nefazodone) - on the activity of rat CYP2B measured as the rate of 16beta-hy...

Drugs known as Selective Serotonin Reuptake Inhibitors (SSRI) are amongst the most commonly described psychotropic drugs. These are used in the treatment of a multitude of Psychiatric and non-psychiatric conditions and are also being explored as potential immunosuppressants/ immunomodulators [1]. SSRIs act by inhibiting the presynaptic reuptake of serotonin at neural synapse. Although instances...

Abstract Indirect agonism has been invoked as part of the mechanism antipsychotic action at dopamine D 2/3 receptors, and more recently a salient neuropharmacological aspect serotonin 5‐HT 2A drug pimavanserin (Pim). We now comment on an article in this volume showing that Pim treatment attenuates deposition Aβ protein brain transgenic Alzheimer's disease model mice. may interfere with by shift...