Doxorubicin (DOX) is very effective chemotherapeutic agent, however it has several major drawbacks. Therefore the motivation for developing novel drug complexes as anticancer agents with different mechanism of action has arisen. The aim of the present study was to evaluate the influence of newly synthesized DOX complexes with selected metals (Mg, Mn, Co, Ni, Fe, Cu, Zn) on apoptosis, cell cycle...

The present study the selected heavy metals such as cadmium (Cd), chromium (Cr), lead (Pb), Manganese (Mn) and cooper (Cu) were determined in water, sediment and gill, liver, muscle of fish H. fossilis, the concentration of Cd, Cr, Pb, Cu Mn and Zn was observed 0.009, 0.056, 0.056, 0.058, 0.049, 0.883, 0.36 mg/l in river water and 3.38, 20.11, 81.53, 258.48, 258.48, 3.40 μg/g in sediment respec...

The effects of plant-microbe interactions between the hyperaccumulator Arabidopsis halleri and eight bacterial strains, isolated from the rhizosphere of A. halleri plants grown in a cadmium- and zinc-contaminated site, were analysed for shoot metal accumulation, shoot proteome, and the transcription of genes involved in plant metal homeostasis and hyperaccumulation. Cadmium and zinc concentrati...

This study was performed to select single nucleotide polymorphisms (SNPs) related to the body burden of heavy metals in Koreans, to provide Korean allele frequencies of selected SNPs, and to assess the difference in allele frequencies with other ethnicities. The candidate-gene approach method and genome-wide association screening were used to select SNPs related to the body burden of heavy meta...

Concentration of metals (Zn, Cu and Pb) in the edible portion of commercially important blood cockle (Anadara granosa) collected from Langkawi Island, Malaysia was analyzed. Samples were collected from 3 different stations namely Kuah (KU), Kuala Triang (KT) and Pantai Kok (PK) during 2009. Heavy metal concentrations were detected using Inductively Coupled Plasma Mass Spectrometry (ICP-MS) with...

Materials and methods A retrospective case-control study was performed. Industry workers from a nonferrous plant and controls were monitored for an 8-year period. During this period, all workers received regular clinical examinations, which included evaluation for smoking status, occupational exposure to noxious non-ferrous metals (lead, Pb; cadmium, Cd), and cardiovascular disease (hypertensio...

The purpose of this study was to evaluate the levels of heavy metal bioconcentration of the mosquitofish (Gambusia affinis) in Shadegan international wetland. Sampling including the water, waterbed sediment and mosquitofish was carried out from the selected sampling sites during October and November 2011, and analyzed by the ICP-OES. Results show that the water has poor qualitative condition, a...

BACKGROUND Environmental and occupational exposure to metals is ubiquitous worldwide, and understanding the hazardous metal components in this complex mixture is essential for environmental and occupational regulations. OBJECTIVE To identify hazardous components from metal mixtures that are associated with alterations in cardiac autonomic responses. METHODS Urinary concentrations of 16 type...

in recent years, environmental pollution by coal mining is a long-established human activity affecting all levels of life with various environmental impacts by generating heavy metals. the presence of heavy metals even in trace amount is toxic and detrimental to all living organisms. the coal mine area in bokaro is one of the “toxic hotspot” in india. bacteria have evolved uptake and efflux mec...

This study was carried out to determine the level of same selected metals namely Cd, Cr, Cu, Fe, K, Mg, Mn, Ni, Pb, Zn, As, Se, Al and V in some imported canned foods and chicken stock purchased from the local market in Riyadh, Saudi Arabia. The measurements were performed using inductively coupled plasma-optical emission Spectrometer (SPECTRO) analytical instruments. The result showed that the...