We initiated a large-scale bidirectional selection experiment in a genetically heterogeneous rat population (N/NIH stock, n = 152) to develop lines of low response trainers (LRT) and high response trainers (HRT) as a contrasting animal model system. Maximal treadmill running distance [meters (m)] was tested before (DIST(1)) and after (DIST(2)) standardized aerobic treadmill training over an 8 w...

OBJECTIVES Exercise improves endothelial dysfunction, the key manifestation of cardiovascular and cerebrovascular disease, and is recommended in both cardiovascular and cerebrovascular rehabilitation. Disagreement remains, however, on the role of intensity of exercise. The purpose of this review was to gather current knowledge on the effects of high-intensity training versus moderate-intensity ...

While endurance exercise training improves cerebrovascular health and has neurotrophic effects within the hippocampus, the effects of stopping this exercise on the brain remain unclear. Our aim was to measure the effects of 10 days of detraining on resting cerebral blood flow (rCBF) in gray matter and the hippocampus in healthy and physically fit older adults. We hypothesized that rCBF would de...

background resistance exercise is recommended as a useful therapeutic tool for the treatment of type 2 diabetes (t2d); however, the frequency of studies is inadequate to establish the precise mechanisms of any association between them. objectives in this study, we aimed to assess the effect of three months of resistance training on tcf7l2 expression in pancreatic tissues, serum insulin and gluc...

objective: exercise activity could be an amendment to polycystic ovary syndrome (pcos). however the acute and chronic effects of various exercise intensities on serum leptin levels are ambiguous. this study investigates the acute and chronic responses of various intensities of exercise on serum leptin levels and weights of female rats with pcos. methods: in this semi-empirical study, 80 adult w...

Introduction: Effects of exercise on different body systems, especially cardiovascular and musculoskeletal systems are evidenced. There is a dynamic homeostatic balance between coagulation and fibrinolysis in normal circulation. Effect of exercise and training on this homeostatic balance has been studied extensively but there are a few studies with regards to analysis of the effects of train...

background and purpose: recent reports suggest that increased homocysteine is a risk factor for heart disease. on the other hand, regular exercise and supplementation of omega-3 fatty acids have been effective in reducing these diseases. the purpose of this study was to evaluate the interaction effect of 8 weeks of aerobic training and omega-3 fatty acid supplementation on plasma homocysteine c...