Acne vulgaris (AV) is the most common and multifactorial skin disease in adolescents affecting pilosebaceous unit that involves hormonal imbalance, increased sebum production, bacterial colonization, which causes both physical psychological disorders. Cutibacterium acnes considered one of key contributing factors even though many colonies are on healthy skin. induces lipogenesis production sebu...

Isotretinoin is one of the therapeutic options for rosacea. However, the response of erythema to treatment with isotretinoin is usually slow and incomplete with common (0.5-1 mg/kg/day) or low (10 mg/day) doses. This study investigated the efficacy of, and relapse on, 20 mg/day isotretinoin treatment in rosacea, with the aid of instrumental measurement of facial erythema and sebum levels. A 20 ...

BACKGROUND AND OBJECTIVE A minimally invasive fractional radiofrequency microneedle (FRM) device has been used in skin rejuvenation and acne scars, and a recent pilot study demonstrated the positive therapeutic effect on acne. We evaluated the efficacy of FRM device for acne vulgaris in Asians and conducted objective measurement to assess its effect on sebum production. PATIENTS AND METHODS T...

BACKGROUND Seborrheic dermatitis (SD) is a multifactorial disease; Malassezia species play an important role in its pathogenesis. OBJECTIVE We aimed to determine whether a cream containing climbazole/piroctone olamine (C/P cream), antifungal agents with expected efficacy against Malassezia species, could improve SD symptoms. METHODS We instructed 24 patients with mild-to-moderate SD to appl...

Androgens are well known to influence sebum synthesis and secretion. Various factors related to androgen biosynthesis are expressed in human sebaceous glands. In this study, immunohistochemical analysis of human skin specimens from 43 subjects indicated that various androgen-producing and -metabolizing enzymes were functionally localized to sebocytes accumulating lipid droplets and that the exc...

Skin health is characterized by heterogeneous system of water and lipids in upper layers providing protection from external environment and preventing loss of vital components of the body. Skin hydration (moisture) and sebum (skin surface lipids) are considered to be important factors in skin health; a right balance between these components is an indication of healthy skin and plays a central r...

The rate of sebum excretion from the forehead skin of patients with early breast cancer was found to be just significantly higher than in age-matched control women. This may indicate that some breast cancer patients have an increase in circulating or tissue-bound sebotrophic hormones, or a decrease in their inhibitors.

In this article the possibilities of functioning of breast as an attractant to male and leading to a long lasting relation in many cases are discussed. The three mechanisms discussed are on the basis of visual stimuli, pheromone and other chemicals like sebum.

Rosacea is a chronic inflammatory condition that affects the skin of the face and the eyes. The aetiology of rosacea is not clearly established but increasing evidence suggests a potential role for bacteria in the induction of the condition. A role for Bacillus oleronius, originally isolated from within a Demodex folliculorum mite, in the aetiology of the condition has been suggested. The aim o...