Scleroderma-like cutaneous lesions have been found in many pathological conditions and they the clinical appearance of sclerotic or scleroatrophic lesions. Affected skin biopsies described histopathological changes similar to those scleroderma located strictly on systemic sclerosis. These can be inflammatory diseases with autoimmune substrate (generalized morphea, chronic graft versus host dise...

Sir, Lichen myxedematosus (LM) is a rare pathology, described for the ® rst time by Dubreuilh (1) in 1906, characterized by the accumulation of mucinous material in the dermis, with no disorder in the thyroid gland, and usually associated with paraproteinemia. In 1953, Montgomery & Underwood (2) classi® ed LM into 4 clinical types: (1) a generalized lichenoid eruption, later denominated sclerom...

BACKGROUND Scleromyxoedema is a variant of papular mucinosis affecting the skin and internal organs. The different therapeutic approaches proposed for scleromyxoedema are still unsatisfactory. Intravenous immunoglobulin (IVIg) has been successfully employed in the treatment of connective tissue diseases and vasculitides. PATIENTS The successful treatment of three cases of scleromyxoedema with...

Nephrogenic fibrosing dermopathy/nephrogenic systemic fibrosis (NSF) is an emerging scleromyxedema-like cutaneous disorder of unknown cause that is seen in patients with renal failure, and the number of reported cases has grown significantly since its first recognition. Recent case reports associated the use of gadolinium (Gd3+)-based contrast agents with the development of NSF. Herein is repor...