BACKGROUND The aim of this study was to determine the effects of amniotic membrane impregnated with betamethasone on regeneration of transected sciatic nerve injury in adult albino Wister rats. METHODS In this research, 42 male adult rats were divided into six equal groups. 1) Normal (intact) group: healthy rats without any injury; 2) CONTROL GROUP: sciatic nerve was cut and sutured; 3) Sham ...

Transplantation of bone marrow mesenchymal stem cells (BMSCs) has been developed as a new method of treating diseases of the peripheral nervous system. While netrin-1 is a critical molecule for axonal path finding and nerve growth, it may also affect vascular network formation. Here, we investigated the effect of transplanting BMSCs that produce netrin-1 in a rat model of sciatic nerve crush in...

The incidence of iatrogenic peripheral nerve injury during hip arthroplasty procedures has been reported to be between 0.6 and 1.3 percent. The relative risk of nerve palsy is higher in certain groups of patients such as women, patients with developmental dysplasia of the hip, and those who have undergone revision arthroplasty. In this study, the dynamic relationship between the acetabulum and ...

OBJECTIVES To systematically record rat facial nerve recovery following crush injury to the main trunk with respect to ocular and vibrissial function and to compare the rates of facial and sciatic nerve recovery from crush injury in the same animals. This serves as a means of validating the functional parameters of facial nerve recovery against the well-known measure of hind limb function, the ...

Sciatic nerve injury and dysfunction is not an uncommon cause of lower extremity symptoms in a musculoskeletal practice. The sciatic nerve derives its nerve fibers from the L4, L5, S1, S2, and S3 nerve roots. The sciatic nerve arises from the lumbosacral plexus and is composed of two distinct trunks: the lateral (peroneal division) and the medial (tibial division). The peroneal and the tibial d...

An experimental crush injury to the sciatic nerve, with a crush force of 49.2 N (pressure p=1.98x10(8) Pa), was inflicted in 30 male rats (Wistar). A control group (sham), with the same number of rats, was also operated upon exactly as the experimental group but without the crush injury. We tested the sensory and motor recovery of the sciatic nerve with Hargreaves method, using an apparatus fro...

OBJECTIVE Crush injury to the sciatic nerve causes oxidative stress. Alfa Lipoic acid (a-LA) is a neuroprotective metabolic antioxidant. This study was designed to investigate the antioxidant effects of pretreatment with a-LA on the crush injury of rat sciatic nerve. METHODS Forty rats were randomized into four groups. Group I and Group II received saline (2 ml, intraperitoneally) and a-LA (1...

INTRODUCTION Dexamethasone and vitamin B(12) are currently used in the clinic to treat peripheral nerve damage but their mechanisms of action remain incompletely understood. In this study we hypothesized that dexamethasone and vitamin B(12) promote the production of endogenous neurotrophic factors, thereby enhancing peripheral nerve repair. MATERIAL AND METHODS Ninety-six adult male Wistar ra...

equisetum telmateia (equisetaceae) seems to have anti inflammatory and antioxidant properties. in the present study, the neuroprotective effects of organic and inorganic silica were investigated on spinal cord alpha motoneuron of rats after injury of sciatic nerve. after highly compression of sciatic nerve in 42 wistar rats, the injured rats were divided into sham (n= 6) and two experimental gr...

Peripheral nerve injuries can cause disabilities, social or economic problems. Melatonin, the secretory product of the pineal gland has antioxidant and anti-inflammatory actions. The aim of the present study was to investigate the effect of melatonin on the recovery of sciatic nerve after injury, comparing its effect when given in the light or the dark periods. Forty adult male Albino rats were...