In this article we describe recent advances in imaging technologies that quantify the topography of the optic nerve head and retinal nerve fibre layer and their role in diagnosing glaucoma. These technologies include optical coherence tomography (OCT), scanning laser polarimetry (SLP, GDx) and confocal scanning laser ophthalmoscopy (CSLO, HRT). A review of recently published literature was carr...

Assessment of the retinal nerve fiber layer (RNFL) is appealing for use in clinical trials of glaucoma neuroprotection, as it is directly correlated with loss of ganglion cells, which is assumed to be a primary event in glaucomatous damage. Qualitative assessment of the RNFL includes ophthalmoscopy, color stereophotography, and red-free monochromatic photography. In contrast, confocal scanning ...

AIMS Scanning laser polarimetry is a new technique allowing quantitative analysis of the retinal nerve fibre layer in vivo. This technique was employed to investigate the variation of the retinal nerve fibre layer thickness in a group of normal subjects of different ages and ethnic groups. METHODS 150 normal volunteers of different ages and ethnic groups were recruited for this study. Three c...

This study quantified normal age-related changes to the photoreceptor axons in the central macula using the birefringent properties of the Henle fiber layer. A scanning laser polarimeter was used to acquire 15° × 15° macular images in 120 clinically normal subjects, ranging in age from the third decade to the eighth. Raw image data of the macular cross were used to compute phase retardation map...

OBJECTIVE To evaluate morphological parameters of optic disc and retinal nerve fiber layer (RNFL) examined with confocal laser tomography (HRT3) and laser polarimetry (GDx-VCC) in a normal population, and analyze correlations of these parameters with demographic variables. PATIENTS AND METHODS Cross-sectional study in the context of a glaucoma screening campaign in the primary care center of ...

AIMS To devise a method to describe and quantify the shape of polar profiles obtained with the scanning laser polarimeter and to compare this measurement with other polar profile measurements in a series of normal subjects and glaucoma patients. METHODS Scanning laser polarimetry was performed on 54 normal subjects and 74 glaucoma patients. The retardation values obtained from one randomly ch...

Imaging polarimetry was used to examine different components of neovascular membranes in age-related macular degeneration. Retinal images were acquired with a scanning laser polarimeter. An innovative pseudocolor scale, based on cardinal directions of color, displayed two types of image information: relative phases and magnitudes of birefringence. Membranes had relative phase changes that did n...