The Committee* appointed by the Society beg to present their Report on the evidence which the present state of medical knowledge supplies as to the conditions affecting the protection afforded by vaccination against death-f* by small-pox occurring in persons contracting that disease. In the first instance they desire to cordially thank those medical men who have assisted them to obtain the info...

Long-term protection of rabbits that had been vaccinated with two doses of a recombinant protective antigen (rPA) vaccine was examined against an aerosol spore challenge with the Ames isolate of Bacillus anthracis at 6 and 12 months. At 6 months after the primary injection, survival was 74.1% (20/27) with quantitative ELISA titer of 22.3 microg of anti-rPA IgG per millilitre and toxin neutraliz...

By contrasting Hippocratic and nineteenth century theories of disease, this paper describes important conceptual changes that have taken place in the history of medicine. Disease concepts are presented as causal networks that represent the relations among the symptoms, causes, and treatment of a disease. The transition to the germ theory of disease produced dramatic conceptual changes as the re...

1. The blood cholesterol of rabbits on a normal diet without added cholesterol is increased only slightly (19 per cent) by thyroidectomy. 2. In rabbits with a hypercholesterolemia due to long continued cholesterol feeding, thyroidectomy causes a marked rise (137 per cent) in the blood cholesterol. This rise is usually maintained. 3. When long continued cholesterol feeding has failed to cause a ...

und 5-Joduracil wurde bei 260 und 280 m//, von Cytosin bei 265 und 280 m/u, von Naphthoimidazol bei 230 und 240 m/*, von 5.6-Dimethylbenzimidazol bei 245 und 260 m/ii, von 6-Azauracil bei 250 und 280 mju und von 8-Azaguanin bei 255 und 275 m/u verfolgt. Eine Inkubationsdauer von 60 Min. reicht im allgemeinen vollständig, um einen deutlichen Effekt zu erhalten. Bei längerer Inkubation (3 Stdn.) ...

The activity of 5-aminolevulinate dehydratase (ALAD) in rabbit blood is significantly inhibited by tin. Intravenous administration of tin (0.48 or 4.8 mumol/kg body weight) causes a decrease in the activity of the enzyme by 60% or 94% respectively. The effects of tin and lead on ALAD differ: inhibition by tin is not affected by pre-incubation at 50-60 degrees C, whereas the inhibitory effect of...

This study was conducted to determine whether atherosclerotic lesions regressed in rabbits that were placed on a normal, low cholesterol diet. Rabbits (n = 16) were fed a 2% cholesterol diet for 90 days; nine rabbits were killed, and the remaining seven rabbits were fed a low cholesterol diet for 7 months.. Appropriate noncholesterol-fed controls were used with each group. After 90 days of chol...

Rabbits 2 to 41 months of age were conditioned in the 500 ms trace eyeblink paradigm to cross-sectionally define the age of onset and the severity of age-associated impairments in acquisition of this relatively difficult hippocampally dependent task. Using a strict behavioral criterion of 80% conditioned responses (CRs), age-associated learning impairments were significant by 24 months of age. ...

Male adult rabbits were divided into five experimental groups and were fed a 2% cholesterol diet using the following schedule: (A) two groups, normal control diet; (B) one group, 60 days continuous diet (60 day); (C) one group, 30 days cholesterol 30 days control diet (3030); (D) one group, 60 days cholesterol, 30 days control diet (60-30). Aortic collagen synthesis was estimated by measuring t...