BACKGROUND Pulmonary hypertension (PHT) is a significant cause of mortality in patients with sickle cell disease (SCD). Few studies on PHT in SCD have been carried out in children. This study aimed to estimate the prevalence of PHT in children with sickle cell anaemia (SCA) and determine its clinical and laboratory correlates. METHODS In this cross sectional study, evaluation involved obtaini...

It is well known that individuals with SCA undergo constant physiological stress even, in steady state. However, there is little information on the relationship between the severity of sickle cell anaemia (SCA) and serum levels of biomarkers of stress. This study therefore determined the serum levels of copeptin, cortisol and CRP in adults with SCA in different severity groups. Sixty adults wit...

Neutrophilia is a useful marker of infection in many clinical settings but it is of limited value in SCA patients in whom neutrophilia with left shift is common even in steady state in the absence of infection. We hypothesize that eosinopenia may be a more reliable marker of infection in SCA patients. Retrospective analysis of the neutrophil and eosinophil counts of SCA patients in steady state...

Methods The Ore-SUDS (Oregon Sudden Unexpected Death Study) is an ongoing prospective investigation of SCA in the Portland, Oregon, metropolitan area (population approximately 1 million). All cases meeting criteria for SCA were ascertained using multiple sources. Medical records were reviewed to identify clinical conditions that may contribute to SCA risk, and comparisons were made between male...

In medicinal chemistry, it is of central importance to understand structureactivity relationships (SARs) of small bioactive compounds. Typically, SARs are analyzed on a case-by-case basis for sets of compounds active against a given target. However, the increasing amount of compound activity data that is becoming available allows SARs to be explored on a large-scale. Moreover, molecular sca old...

Liberal fluid intake is one of the key management strategies in sickle cell anaemia [SCA] patients in steady state, but less work has been done on the desire of patients to drink water. Using the Visual Analogue Scale we studied thirst perception [TP] in 20 euhydrated SCA patients and 28 control [HbA] subjects, as well as during dehydration in 13 SCA patients and 9 HbA subjects. Serum and urine...

Somatostatin analogs and dopamine agonists are clinically used for medical therapy of functioning pituitary tumors, such as growth hormone- and prolactin-secreting tumors, however, their effects on ACTH-secreting tumors are controversial. This study was aimed to determine whether somatostatin receptor (SSTR) subtype (1-5) and dopamine receptor type 2 (D2R) are differentially expressed in pituit...

AIM Superior cerebellar artery (SCA) aneurysms are uncommon vascular lesions, thus data about their presentation and clinical management are limited. Our aim was to determine clinical presentation, angiographic findings and mid and long-term clinical and imaging results of endovascular treatment of 49 patients with SCA aneurysm. MATERIAL AND METHODS Forty-nine patients with SCA aneurysms unde...

Solid serous cystadenoma (SCA) of the pancreas is a rare type of pancreatic solid tumors. Postoperative pathological evaluation is of particular importance for distinguishing solid SCA of the pancreas from other pancreatic solid tumors. Here we present 2 cases of solid SCA of the pancreas, both preoperatively diagnosed with pancreatic neuroendocrine tumors. One case had positive OctreoScan test...