Sarcomatoid renal cell carcinoma is a rare tumour of the kidney whichaccounts for l%of renal neoplasms inadults and has been reported in ito 6.5% of renal cortical carcinomas in different studies The diagnostic morphological feature of this cancer is the intermingling of typical renal cell carcinoma with a component of sarcomatoid features, comprising of spindle cells without organisation or re...

Sarcomatoid combined hepatocellular-cholangiocarcinoma is an extremely rare primary hepatic malignancy and only a few cases have been reported. Herein, we report a case of combined hepatocellular-cholangiocarcinoma with sarcomatoid changes in a 52-year-old man, who had a history of liver cirrhosis and transarterial chemoembolization. The resected liver revealed a mass of 4.5×3.5 cm. Microscopic...

Atrial fibrillation is commonly seen in atrial dilation and fibrosis of the atrium. As cancer patients live longer, cardiac metastasis is an increasingly common finding in this population, occurring in up to 14% of cancer patients. This problem holds significance in relation to operability and type of treatment. Cardiac invasion through the pulmonary veins is a rare occurrence, as is sarcomatoi...

Adrenocortical sarcomatoid carcinoma (ASC) is an extremely rare variant of adrenocortical carcinoma (ACC). Its relative rarity and its characteristic histological pattern of both epithelioid and sarcomatoid components may pose diagnostic challenges which influence treatment. Here, we report a case of ASC in a 58 year-old man presenting with increasing abdominal pain and associated abdominal blo...

Sarcomatoid carcinoma of the prostate is a rare variant of prostatic cancer, with less than 100 cases reported in the literature up to date. Tumors are most commonly composed of an admixture of both malignant glandular and spindle cell elements. The sarcomatoid component can vary from 5 to 99%. We report a case of a 76-year old Caucasian man who underwent transurethral resection of the prostate...

Salivary duct carcinoma (SDC) is a rare and high-grade malignant tumor that arises predominantly in a major salivary gland and bears a striking histological resemblance to high grade ductal adenocarcinoma of breast. The sarcomatoid SDC is a rare subtype that comprises of both epithelial and sarcomatoid components. The authors describe a case of sarcomatoid SDC of parotid gland. Its histological...

Spindle cell proliferations of diverse types which vary greatly in their behavior may occur in the urinary bladder. Some of them such as the inflammatory pseudotumor and the postoperative spindle cell nodule are reactive and clinically benign although they may be responsible for significant symptoms. On the other hand, certain other lesions such as sarcomatoid carcinomas are typically highly ma...

UNLABELLED Sarcomatoid metastatic renal cell carcinoma (mRCC) is associated with a poor prognosis, and the biology of the disease has been inadequately characterized. RNA sequencing (RNA-seq) was performed on adjacent benign, clear cell, and sarcomatoid components from clinical specimens with sarcomatoid mRCC. M phase and cell-cycle pathways were enriched in sarcomatoid versus adjacent clear ce...