نتایج جستجو برای: sarcomas
تعداد نتایج: 6462 فیلتر نتایج به سال:
The reticulum cell sarcomas induced by Friend leukemia virus (FLV) and the lymphomas induced by the Friend virus-associated lymphatic leukemia virus (LLV) have been investigated for both their antigenic relationships and the presence in them of common tumor-specific transplantation antigens. Since noninfectious reticulum cell sarcomas contain ing the Friend virus genome were available, this was...
Sarcomas are distinctly heterogeneous tumors and a variety of subtypes have been described. Although several diagnostic explorations in the past three decades, such as identification of chromosomal translocation, have greatly improved the diagnosis of soft tissue sarcomas, the unsolved issues, including the limited useful biomarkers, remain. Emerging reports on miRNAs in soft tissue sarcomas ha...
Genetically engineered mouse models that employ site-specific recombinase technology are important tools for cancer research but can be costly and time-consuming. The CRISPR-Cas9 system has been adapted to generate autochthonous tumours in mice, but how these tumours compare to tumours generated by conventional recombinase technology remains to be fully explored. Here we use CRISPR-Cas9 to gene...
Murine sarcoma virus (Moloney) of mouse origin induced progressively growing local sarcomas in newborn OsborneMendel rats. Cell-free extracts prepared from the rat sar comas were oncogenic in newborn mice and in newborn, 2wpck-old, and 4-week-old Osborne-Mendel rats. The sarcomas were readily transplan table in Osborne-Mendel rats of the same age groups. Tumors in the early transplant generatio...
p53 is a 53-kDa nuclear protein that is associated with malignant transformation in several tumor model systems. In a survey of 134 human carcinomas, sarcomas, leukemias, and lymphomas obtained at surgery or from peripheral blood, we found rearrangements of the p53 gene only in osteogenic sarcomas (3 of 6 osteogenic sarcomas examined). Normal tissue from one of these patients had an unrearrange...
Primary cardiac sarcomas are rare and histologically diverse, with single tumors able to demonstrate histological heterogeneity. Consequently, they often misdiagnosed as other common tumors, such myxoma or metastatic malignancies. Incorrect diagnoses can result in incomplete surgeries, inadequate treatment regimens, early recurrence. In our experience, based on the diverse cytological character...
Breast sarcomas arise from connective tissues of the breast and account for fewer than 1% all malignancies. They can be subclassified as primary sarcomas, which de novo are histologically diverse, secondary a result radiation or lymphedema most commonly angiosarcomas. Two other tissue neoplasms that occur within include phyllodes tumors desmoid tumors, exhibit spectrum behaviors. Malignant biol...
DNA-aneuploidy may reflect the malignant nature of mesenchymal proliferations and herald gross genomic instability as a mechanistic factor in tumor genesis. DNA-ploidy and -index were determined by flow cytometry in canine inflammatory or neoplastic mesenchymal tissues and related to clinico-pathological features, biological behavior and p53 gene mutational status. Half of all sarcomas were ane...
BACKGROUND Head and neck sarcomas are exceedingly rare and they include 4% - 10% of all sarcomas and less than 1% of all neoplasm of head and neck. OBJECTIVES The aim of this study is to evaluate the epidemiological characteristics of head and neck sarcomas of patients in Isfahan, Iran. PATIENTS AND METHODS In this retrospective study, from the 16000 patients whose files were evaluated, the...
Pediatric soft tissue sarcomas are rare tumors of childhood, frequently characterized by specific chromosome translocations. Despite improvements in treatment, their clinical management is often challenging due to the low responsiveness of metastatic forms and aggressive variants to conventional therapeutic approaches, which leads to poor overall survival. It is widely thought that soft tissue ...
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