Background: Patients with Graves’ disease exhibit a considerable rate of relapse after treatment with antithyroid drugs and require ablative therapy. Objective: The purpose of this study was to evaluate variables which can be used as prognostic factors in predicting the outcome of Graves’ disease after treatment with antithyroid drugs. Methods: Age, sex, duration of antithyroid drug therapy, pr...

background: patients with graves’ disease exhibit a considerable rate of relapse after treatment with antithyroid drugs and require ablative therapy.   objective: the purpose of this study was to evaluate variables which can be used as prognostic factors in predicting the outcome of graves’ disease after treatment with antithyroid drugs.   methods: age, sex, duration of antithyroid drug therapy...

Iodine is a particularly relevant element in thyroid gland physiology. Although healthy follicular cells have several mechanisms which allow them to adapt to marked changes in iodine provision, both iodine deficiency and excess may cause dysfunction in a diseased thyroid gland. A 26-year-old female patient with an unremarkable history attended her family physician reporting fatigue for several ...

The iodination of chlorinated aromatic compounds using Ag(2)SO(4)/I(2), AgSbF(6)/I(2), AgBF(4)/I(2) and AgPF(6)/I(2) offers access to iodoarenes that are valuable intermediates in organic synthesis. Specifically, iodination of phenols, anisoles and anilines with a 3,5-dichloro substitution pattern preferentially yielded the ortho, para and para iodinated product, respectively. In the case of ch...

A new palladium-catalyzed picolinamide (PA)-directed ortho-iodination reaction of ε-C(sp(2))-H bonds of γ-arylpropylamine substrates is reported. This reaction proceeds selectively with a variety of γ-arylpropylamines bearing strongly electron-donating or withdrawing substituents, complementing our previously reported PA-directed electrophilic aromatic substitution approach to this transformati...

the kinetics of iodination of the phenol and substituted phenols using pyridiniumiodochloride in methanol has been studied under varying conditions. the rates show first orderkinetics each in pyridinium iodochloride and phenols. the rates of reactions are measured atdifferent temperature and activation parameters for all phenols computed. hammett plot is foundto be valid and the corrletion betw...