in this study, liquid-liquid extraction process in a kuhni extraction column was modeled and simulated. a non-equilibrium dynamic model was developed for modeling liquid-liquid extraction processes based on a rate-based model. the model equations are inclusive of partial and ordinary differential equations which were discretized in column height direction. the population balance model was used ...

Novel dispersive liquid-liquid microextraction (DLLME), coupled with high performance liquid chromatography with photodiode array detection (HPLC-DAD) has been applied for the extraction and determination of cyproheptadine (CPH), an antihistamine, in human urine samples. In this method, 0.6 mL of acetonitrile (disperser solvent) containing 30 µL of carbon tetrachloride (extraction solvent) was ...

Novel dispersive liquid-liquid microextraction (DLLME), coupled with high performance liquid chromatography with photodiode array detection (HPLC-DAD) has been applied for the extraction and determination of cyproheptadine (CPH), an antihistamine, in human urine samples. In this method, 0.6 mL of acetonitrile (disperser solvent) containing 30 µL of carbon tetrachloride (extraction solvent) was ...

recovery of metabolites from fermentation broth by solvent extraction can be used to optimize fermentation processes. end-product reutilization, low product concentration, large volumes of fermentation broth and the requirements for large bioreactors, in addition to the high cost largely contributed to the decline in fermentative 2, 3-butanediol production. extraction can successfully be used f...

The economic and effective method for preparation of R-(-)-ibuprofen by diastereomer crystallization was developed. R-(-)-ibuprofen was resolved from racemic ibuprofen by forming R-(-)-ibuprofen-R-(+)-alpha-methylbenzylamine diastereomeric salt with R-(+)-alpha(-methylbenzylamine and crystallization. The purity of R-(-)-ibuprofen-R-(+)-alpha-methylbenzylamine diastereomeric salt was tested and ...

The review of the RP HPLC analysis of basic psychotropic drugs is presented. It contains sample preparation methods with centrifugation, protein precipitation, liquid-liquid extraction (LLE), dispersive liquid-liquid microextraction (DLLME), solid-phase extraction (SPE), solid-phase microextraction (SPME), microwave-assisted extraction (MAE) and RP-HPLC analysis. Chromatographic behavior of bas...

Ionic liquid-based dispersive liquid–liquid microextraction (IL– –DLLME) coupled with high performance liquid chromatography (HPLC) with UV detection was developed for the simultaneous extraction and determination of nickel, cobalt, copper and zinc ions. In the proposed approach, salophen (N,N'-bis(salicylidene)-1,2-phenylenediamine) was used as a chelating agent, the ionic liquid, 1-hexyl-3-me...

Seven liquid solvent systems--dichloromethane, dichloromethane-pentane (1:1), freon 113, diethyl ether-pentane (1:1 and 1:9), ethyl acetate-pentane (with and without an additional salting-out effect) (1:3 and 1:20), and seven solid-phase extraction (SPE) systems (Amberlite XAD-2, 4, 7, and 16; Porapak Q; C8; and C18)--are comparatively studied. The distribution coefficients between the extracti...