Salivary gland neoplasms have always been an field of interest for head neck and tumors because of its diversity in histogenesis and morphogenesis. Its of keen interest that all benign tumors arise from major salivary glands whereas on the other side all malignant arise from minor salivary glands. Reason for the above criteria can be understood only when a complete knowledge and understanding o...

Sialolipoma, a rare tumor of the salivary gland, is a recently described variant of salivary gland lipoma. Oncocytic sialolipoma was first described by Pusiol et al. in 2009. We report the case of an oncocytic sialolipoma of the submandibular gland in a 43-year-old female. Excision of the tumor was performed with preservation of the submandibular gland. The tumor had a thin, fibrous capsule and...

OBJECTIVE Salivary gland neoplasms pathogenesis has not been well established. DNA methylation occurs when methyl groups are added to cytosine nucleotides in specific areas of the gene by the enzyme DNA methyltransferase (DNMT). This chemical modification can alter gene expression without altering DNA sequence. While DNMT3a is mostly involved in de novo methylation, DNMT1 acts as a maintenance ...

Among salivary gland neoplasms, metastasizing pleomorphic adenoma (MPA) constitutes an extremely rare group of tumors. The present paper reports a case of pleomorphic adenoma (PA) in submandibular gland that, after more than 30 years of initial treatment, recurred and metastasized to ipsilateral neck lymph nodes and parotid gland. In an attempt to elucidate the malignant behavior of metastasizi...

Polymorphous low‐grade adenocarcinoma (PLGA) is difficult to diagnose due to its indolent clinical presentation and due to its morphological diversity that includes several microscopic patterns. Distinguishing it from high‐grade tumors of salivary gland is important, as the management and prognosis of this tumor differ. We report a considerably rare case of PLGA in retromolar area highlighting ...

Hybrid carcinomas are rare neoplasms which are characterized by two different types of tumors localized in a single topographic region of the lesion. Parotid gland is the most common involvement site of hybrid carcinomas among salivary glands. The aggressiveness of the hybrid tumor depends on its high-grade component. In this article, we present a 71-year-old male case with the left parotid gla...

The studies described in this thesis were carried out at the departments of Oral and Contents Chapter 1: General Introduction 9 Chapter 2: Variations in mucins and mucin-associated carbohydrate 25 antigens expression in mucoepidermoid carcinomas Chapter 3: High number of chromosomal copy number aberrations 43 inversely relates to t(11;19)(q21;p13) translocation status in Mucoepidermoid Carcinom...

OBJECTIVE Differentiating between adenoid cystic carcinomas (ACCs), polymorphous low-grade adenocarcinomas (PLGAs), and the monomorphic adenomas (including canalicular adenomas, trabecular adenomas, and basal cell adenomas) can present a diagnostic challenge, especially when examining tissue obtained from small incisional or fragmented biopsies. Recent studies have revealed that overexpression ...

Tumors of the parapharyngeal space account for 0.5% of head and neck neoplasms. The parapharyngeal space is actually a potential space located lateral to the upper pharvnx. This bilateral fat containing region extends from the skull base to the hyoid bone. The parapharyngeal space is further compartmentalized by thick fascial layers that direct tumor growth. Among the salivary gland neoplasms, ...

The expression of sex hormone receptors in some tumors suggests a role for these receptors in tumor pathogenesis and therapy. Previous studies of the expression of estrogen and progesterone receptors in salivary gland tumors have reported conflicting results. We evaluated the immunohistochemical expression of androgen, estrogen, and progesterone receptors (AR, ER, and PR) in a series of 78 form...