background: saffron is the dried stigmata of the flowers of saffron (crocus sativus l., iridaceae). saffron is well known for the treatment of gastric disorders in traditional medicine.   objectives: in the search for new potential antiulcer agents, the effects of the ethanol extract of saffron and its active constituents crocin and safranal as compared with omeprazole against gastric ulcer ind...

background: obesity is pandemic worldwide and a strong risk factor for cardio-metabolic disorders. the few approved anti-obesity drugs have poor efficacy and safety profile. thus, there is an urgent need for new anti-obesity agents. according to the traditional medicine and a clinical trial, saffron may have anorexigenic and anti-obesity effects which need further investigation. objectives: eva...

Objective(s): Ischemia/reperfusion (I/R) injury of spinal cord is leading to the paraplegia observed. In this study, we investigated the protective effect of the saffron extract on spinal cord I/R injury. Materials and Methods: Thirty five male Sprague-Dawley rats were divided into 5 groups: intact, sham surgery, normal saline (NS), low dose saffron aqua extract, high dose saffron aqua extract....

background: angiogenesis, which is required for embryonic development and many physiological events, plays crucial role in many pathological conditions such as tumor growth and metastasis. recent studies indicate anticancer and antitumor properties of saffron against human cancers. many processes are affected by electromagnetic field (emf) and its effect on proliferation and gene expression wer...

Article history: Received on: 21/09/2015 Revised on: 22/10/2015 Accepted on: 15/11/2015 Available online: 27/12/2015 Aim: The aim of the present study was to assess the activity of Nelumbo nucifera Gaertn. Petal extract (NNPE) in tubular enzymes and in urinary albumin of Gentamicin (GM) induced renotoxic rats. Material and methods: The study was conducted for fourteen days in twenty-four rats i...

introduction: it has been reported that acute administration of morphine impairs learning and memory processes in rats. furthermore, recent studies showed that saffron extract improved ethanol-induced impairments of learning behaviors in mice, and also prevented ethanol-induced inhibition of hippocampal long-term potentiation. it can be postulated that there are some common mechanisms responsib...

The ability of high (6.73) and low (5.02) pH solutions of lead acetate precipitate of H. rosasinensis petal anthocyanin extract to prevent carbon tetrachloride (CCl4) induced lipid peroxidation in rats has been investigated using plasma malondialdehyde (MDA) level as an index of the process. Relative to its value in the plasma of CCl4 treated extract-free rats, the high pH form (pH 6.73; blue p...

  Background: Saffron is the dried stigmata of the flowers of saffron (Crocus sativus L., Iridaceae). Saffron is well known for the treatment of gastric disorders in traditional medicine.   Objectives: In the search for new potential antiulcer agents, the effects of the ethanol extract of saffron and its active constituents crocin and safranal as compared with omeprazole against gastric ulcer i...

BACKGROUND Saffron extract, a natural product, has been shown to induce apoptosis in several tumor cell lines. Nevertheless, the p53-dependency of saffron's mechanism of action in colon cancer remains unexplored. MATERIAL AND METHODS In order to examine saffron's anti-proliferative and pro-apoptotic effects in colorectal cancer cells, we treated two p53 isogenic HCT116 cell lines (HCT wildtyp...

Modern medicine is currently marked by an increased interest in herbal pharmaceutical drugs traditionally applied folk a significant number of diseases. In this regard, saffron (Crocus sativus L. Iridaceae) particular importance. This paper presents the results study effects Azerbaijan-grown on blood level follicle-stimulating hormone (FSH) female rats, as well testosterone male rats. se...