نتایج جستجو برای: safety testing
تعداد نتایج: 589478 فیلتر نتایج به سال:
Abstract The passive safety of the vehicle is ensured by designing optimized restraint systems to protect occupants during accident. safety-belts have role restraining car on seat an impact or in event a rollover. Their retention prevents minimizes between and interior components passenger compartment. Two simplified models structures are proposed determine strength anchorages. test anchorage f...
Nonclinical safety testing of new biotherapeutic entities represents its own challenges and opportunities in drug development. Hot topics in this field have been discussed recently at the 2nd Annual BioSafe European General Membership Meeting. In this feature article, discussions on the challenges surrounding the use of PEGylated therapeutic proteins, selection of cynomolgus monkey as preclinic...
The accelerating production and use of engineered nanomaterials (NMs) raises questions about the safety of this new technology. To avoid the possible hazards associated with NMs requires proper regulation. How should toxicity testing be addressed and can standard tests for assessment of safety of chemicals be applied to NMs? What are the major limitations of NM safety testing and is the current...
Designing and implementing security-critical systems correctly is difficult. In practice, most vulnerabilities arise from bugs in implementations. We present work towards systematic specification-based testing of security-critical systems using the CASE tool AutoFocus. Cryptographic systems are formally specified with state transition diagrams, a notation for state machines in the AutoFocus sys...
Integrated testing strategies (ITS), as opposed to single definitive tests or fixed batteries of tests, are expected to efficiently combine different information sources in a quantifiable fashion to satisfy an information need, in this case for regulatory safety assessments. With increasing awareness of the limitations of each individual tool and the development of highly targeted tests and pre...
Veterinary vaccines in North America are regulated to assure that they are safe, pure, potent and effective. the veterinary biologics industry conducts a number of in vivo and in vitro assays as part of the vaccine development and manufacturing process to assure that vaccines conform to these requirements. the batch or serial release safety test is one such assay. the serial release safety test...
This paper presents the results of a three year research program to develop an automated test-data generation framework to support the testing of safety-critical software systems. The generality of the framework comes from the exploitation of domain independent search techniques, allowing new test criteria to be addressed by constructing functions that quantify the suitability of test-data agai...
Protection of workers and consumers demands that safety testing accurately detects chemicals and products that can cause injury or disease. Chemicals make our lives more comfortable, but accidental and improper exposures to chemical substances continue to have a significant public health impact. According to the Institute of Medicine (2004), more than 4 million poisonings occur annually in the ...
BACKGROUND Capsaicin, the pungent extract of red peppers, has achieved widespread use in clinical research because it induces cough in a dose-dependent and reproducible manner. Although > 2 decades of experience has led investigators to consider capsaicin cough challenge testing a safe diagnostic modality, this issue has not been specifically addressed in the literature. STUDY OBJECTIVES To r...
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