Powell-Sabin splines are C-continuous quadratic splines defined on an arbitrary triangulation. Their construction is based on a particular split of each triangle in the triangulation into six smaller triangles. In this article we give an overview of the properties of Powell-Sabin splines in the context of computer aided geometric design. These splines can be represented in a compact normalized ...

To identify determinants of attenuation in the poliovirus type 1 Sabin vaccine strain, a series of recombinant viruses were constructed by using infectious cDNA clones of the virulent type 1 poliovirus P1/Mahoney and the attenuated type 1 vaccine strain P1/Sabin. Intracerebral inoculation of these viruses into transgenic mice which express the human receptor for poliovirus identified regions of...

Attenuated strains of the Sabin oral poliovirus vaccine replicate in the human gut and in rare cases cause vaccine-associated paralytic poliomyelitis (VAPP). Reversion of vaccine strains toward a pathogenic phenotype is probably one of the main causes of VAPP, a disease most frequently associated with type 3 and type 2 strains and more rarely with the type 1 (Sabin 1) strain. To identify the de...

The Sabin I poliovirus live, attenuated vaccine strain encodes for four amino acid changes (i.e., D53N, Y73H, K250E, and T362I) in the RNA-dependent RNA polymerase (RdRp). We have previously shown that the T362I substitution leads to a lower fidelity RdRp, and viruses encoding this variant are attenuated in a mouse model of poliovirus. Given these results, it was surprising that the nucleotide ...

lop? This question is as simple as it is fundamental to the understanding of the lymphatic system (LS) under physiological and pathological conditions. Moreover, it is also critical for the development of therapeutic interventions. In 1902, the anatomist Florence Sabin published her studies on the development of the earliest lymphatic vessels in pigs [1 ] and thereby laid the foundation for a c...

background: there is unprecedented increase in the processing and packaging of many plant materials into food supplements, herbal medicine, skincare and cosmetic products for human needs. baphia nitida is used for topical skincare products. toluene, a toxic aromatic solvent, is increasingly being used in the production of these skincare and cosmetic products in many industries. this study asses...

MANY SEROLOGICAL surveys using the dye test of Sabin and Feldman (1948) have shown infection with Toxoplasma gondii to be widespread. It occurs with various degrees of frequency in different geographic areas and antibodies have been found in man and many species of animals (Feldman and Miller, 1956; Beattie, 1957; Jacobs, Remington and Melton, 1960; Ludlam and Beattie, 1963). As an infection pr...

1Department of Pathology, MD Anderson Cancer Institute, 1515 Holcombe Boulevard, Houston, TX 77030, USA 2Department of Pathology and Laboratory Medicine, College of Medicine, University of Cincinnati, MSB, 231 Albert Sabin Way, Cincinnati, OH 45221, USA 3Department of Pediatrics and Internal Medicine, College of Medicine, University of Cincinnati, MSB, 231 Albert Sabin Way, Cincinnati, OH 45221...