Part A I. General methods S1-S2 II. Synthesis of boronate esters (Table 1) S3-S6 III. Competition studies (Table 1) S7 IV. Synthesis of haloboronate esters (Scheme 1) S8-S13 V. Selective Suzuki-Miyaura coupling with haloboronate esters (Table 2) S14-S18 VI. Deprotection of boronate esters (Table 2) S19-S22 VII. Total synthesis of ratanhine (Scheme 3) S23-S39 Part B VIII. NMR spectra Part C IX. ...

background: adjuvants are used to increase the immunogenicity of new generation vaccines, especially those based on recombinant proteins. despite immunostimulatory properties, the use of bacterial lipopolysaccharide (lps) as an adjuvant has been hampered due to its toxicity and pyrogenicity. brucella abortus lps is less toxic and has no pyrogenic properties compared to lps from other gram negat...

S19 previous guidelines. These guidelines are not particularly applicable to any specific treatment setting and may need minor modifications to suit the needs of patients in a specific setting. The recommendations are primarily meant for adult patients. The needs of children or the elderly with schizophrenia may be different. Finally, it is expected that recommendations made will have to be tai...