chiral pyrrolidines and pyrrolizidines with spirooxindole ring systems are the central skeletons for numerous alkaloids and pharmacologically important compounds. gelesmine, pseudotabersonine, formosanine, isoformosanine, morroniside and mitraphylline are some of the alkaloids containing spirooxindole ring systems. derivatives of spirooxindole find very wide biological applications as anti micr...

stevia rebaudiana bertoni is a medicinal, perennial and herbaceous plant from asteraceae family with sweet glycosides in its leaves. salinity stress is one of the important limiters in agricultural productions. salinity influences the growth and development of plant by effect on more activities in physiological and morphological characteristics. to study the effect of salinity on morphological ...

the aim of this research was to investigate the efficiency of ldpe films incorporating fifferent nanofillers in extending orange juice shelf life. fresh orange juice packed in different films was assessed for microbial stability, ascorbic acid content, ph, color parameters and sensory quality during 0, 7, 28 and 58 d of storage. mold and yeast growth, acidophil and aerobic mesophil bacteria pop...

17-4ph stainless steel is a martensitic precipitation hardening stainless steel that provides an outstandingcombination of high strength, good corrosion resistance, good mechanical properties, good toughness in both base metal and welds, and short time, low-temperature heat treatments that minimize warpage and scaling. this valuable alloy is widely used in the aerospace, nuclear, chemical, petr...

background: viscerotropic leishmaniasis caused by leishmania tropica poses a significant prob­lem in the diagnosis and treatment management. since differential gene expression is more im­portant in outcome of the infection, we employed proteomic approach to identify potential pro­teins involved in visceralization of l. tropica . methods: the proteomes profiling of l. tropica isolated from cutan...

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background: the aim of present study was to evaluate the protective efficacy of live recombinant l. tarentolae expressing kmp11-ntgp96-gfp fusion as candidates for live engineered recombinant vaccine against visceral leishmaniasis in balb/c mice. methods: kmp-11 and nt-gp96 genes cloned into the pjet1.2/blunt cloning vector and then into pegfp-n1 expression vector. the kmp-11, nt-gp96 and gfp f...

in order to increase the productivity of human interleukin-2 (il-2) as a model protein in the recombinant e.colibl21 (de3), the effect of magnesium acetate and manganese acetate was studied based on full factorial design experiments magnesium acetate and manganese acetate and their interaction exhibited an increasing effect on il-2 expression level upto 25.24%, 16.80% and 23.30%, respectively, ...

multiple sclerosis (ms) is an autoimmune disease characterized by recurrent episodes of demyelination and axonal lesion mediated by cd4+ t cells with a proinflammatory t helper (th)1 and th17 phenotypes, macrophages, and soluble inflammatory mediators. the overactive  pro-inflammatory  th1  cells  and  clonal  expansion  of  b  cells  initiate  an inflammatory cascade with several cellular and ...

the interaction between immune cells and endothelial lining of blood vessels is vital in many processes such as inflammatory and immune responses as well as cancer cell metastasis. the expression level of vcam-1 is regulated by many factors including the promoter activity that is possibly affected by the single nucleotide polymorphisms (snps) present in the promoter. there are previous reports ...