BACKGROUND Anxiety disorders are among the most common psychiatric illnesses, with generalized anxiety disorder (GAD) being one of the most common. Sleep disturbances are highly prevalent in GAD patients. While treatment with pregabalin has been found to be associated with significant improvement in GAD-related sleep disturbance across many controlled clinical trials, mediational analysis has s...

background and objective: obstructive sleep apnea syndrome (osas) is a prevalent disease in adults. limited evidence regarding the effect of severity of sleep apnea and depression on heart rate variability (hrv) indices exists. hence, we decided to focus on the association between hrv and severity of osas based on depression score. materials and methods: a total of 193 patients with confirmed o...

background and purpose: identification of the effects of sleep disturbances on the quality of life could result in proper treatment of patients with heart failure. this study aimed to investigate the relationship between sleep disorders and erectile dysfunction, depression and quality of life in male patients with systolic heart failure. methods: this correlational study was conducted on 100 ma...

background and objective : irritable bowel syndrome (ibs) is a functional gastrointestinal disorder. sleep disturb-ances are known to be common among individuals with this syndrome. this study aimed to determine the relationship between sleep quality and severity of intestinal symptoms in irritable bowel syndrome. materials and methods : this cross-sectional study was carried out among 201 subj...

Sulfur mustard (SM) is a toxic agent that targets several tissues. It is the leading cause of persistent lung disease, progressive deterioration in lung function and mortality among patients. Disturbed sleep and poor quality of sleep are common in SM-exposed patients with chronic respiratory problems. Melatonin is an alternative medication that has been widely used to treat poor sleep quality c...

Introduction  Adenotonsillar hypertrophy is more common in children with sickle cell disease, and can lead to sleep-disordered breathing. Objectives  To determine the frequency of adenotonsillar hypertrophy in pre-school children with sickle cell disease and assess the diagnostic accuracy of the sleep-disordered breathing subscale in the Sleep Disturbance Scale for Children. Method  Observation...

Although obstructive sleep apnea and cardiovascular disease have common risk factors, epidemiologic studies show that sleep apnea increases risks for cardiovascular disease independently of individuals' demographic characteristics (i.e., age, sex, and race) or risk markers (i.e., smoking, alcohol, obesity, diabetes, dyslipidemia, atrial fibrillation, and hypertension). Individuals with severe s...

BACKGROUND & AIMS Sleep disturbance is associated with the development of obesity, diabetes and hepatic steatosis in murine models. Hepatic triglyceride accumulation oscillates in a circadian rhythm regulated by clock genes, light-dark cycle and feeding time in mice. The role of the sleep-wake cycle in the pathogenesis of human non-alcoholic fatty liver disease (NAFLD) is indeterminate. We soug...