GARLIC (Allium sativum, Liliaceae/Alliaaceae) has long been used for medicinal and culinary purpose. Its first medicinal use was reported 400 years ago, and documented medicinal use can be found in a research finding of Louis Pasteur in the 1800s (8). Originally used as a digestive aid and as an antifungal, antibacterial, or antiviral compound (during the World Wars it achieved the nickname Rus...

OBJECTIVE: S-Allyl-L-cysteine (SAC) is a biological active organosulfur component of garlic and has various pharmacological effects. SAC displayed anti-cancer activity but the mechanism unresolved. This study focused on investigating possible apoptotic autophagic effects two human leukemia cell lines: acute promyelocytic (HL-60) chronic myeloid (K562).MATERIAL AND METHODS: Cell cytotoxicity was...

Modular fenchyl phosphinites (FENOPs) containing different aryl units-phenyl (1), 2-anisyl (2), or 2-pyridyl (3)-are efficiently accessible from (-)-fenchone. For comparison of the influence of the different aryl units on enantioselectivities and reactivities, these FENOPs were employed in Pd-catalyzed allylic alkylations. The strongly chelating character of P,N-bidentate 3 is apparent from X-r...

Alzheimer’s disease (AD) is a neurodegenerative disease and the leading cause of dementia worldwide. Epidemiological studies support the important role of diet in prevention and improvement of AD. In Traditional Persian Medicine (TPM), there is multiple dietary guidelines to prevent and alleviate dementia and memory impairment. Pharmacological studies have been shown that most of the TPM-recomm...

Cabbage contains the glucosinolate sinigrin, which is hydrolyzed by myrosinase to allyl isothiocyanate. Isothiocyanates are thought to inhibit the development of cancer cells by a number of mechanisms. The effect of cooking cabbage on isothiocyanate production from glucosinolates during and after their ingestion was examined in human subjects. Each of 12 healthy human volunteers consumed three ...

The present study was designed to evaluate the beneficial synergistic effects of S-allyl Cysteine (SAC) and Taurine (TAU) on hyperglycemia, lipid profile renal damage markers in type 2 diabetes mellitus (T2DM) rats. Experimental T2DM developed by administering an intraperitoneal single dose nicotinamide (NA; 230 mg/kg) streptozotocin (STZ; 65 mg/ kg) adult Control diabetic rats were treated wit...