A new method for the direct synthesis of imines from alcohols and amines is described where hydrogen gas is liberated. The reaction is catalyzed by the ruthenium N-heterocyclic carbene complex [RuCl2(IiPr)(p-cymene)] in the presence of the ligand DABCO and molecular sieves. The imination can be applied to a variety of primary alcohols and amines and can be combined with a subsequent addition re...

The cellular uptake and subcellular distribution including adduct formation with genomic DNA and uptake into mitochondria of two ruthenium(iii)-based drugs in clinical trials, KP1019 and NAMI-A, and cisplatin, was investigated in cisplatin sensitive and resistant A2780 human ovarian carcinoma cells. These data indicate that reduced metal uptake into mitochondria in combination with increased bi...

Ruthenium complexes are an object of great attention in the field of medicinal chemistry because of their selective antimetastatic properties and low systemic toxicity in comparison to cisplatin, the widely used antitumor drug. Ruthenium-para-cymene-μ-O-dichloride, a newly synthesised Ruthenium compound was used against Dalton’s lymphoma in vivo and in vitro to examine the cytotoxicity of the d...

The bimetallic Fe-Ru oxide nanoparticles were synthesized in the liquid-phase plasma (LPP) method which employed iron chloride and ruthenium chloride as precursors. The active species (OH·, Hα, Hβ, and O(I)) and the iron and ruthenium ions were observed in the plasma field created by the LPP process. The spherical-shaped bimetallic Fe-Ru oxide nanoparticles were synthesized by the LPP reaction,...

The kinetics of the ruthenium-promoted cis,cis to trans,trans isomerization of 1,1,2,2,5,5,6,6-octamethyl-1,2,5,6-tetrasilacycloocta-3,7-diene were investigated. Incubation of a ruthenium alkylidene complex, (Cy(3)P)RuCl(2)(==CHPh)Ru(p-cymene)Cl(2), in CD(2)Cl(2) for 5 days at 40 degrees C afforded a catalytically active ruthenium species that was shown to be responsible for promoting the isome...

Ruthenium active species containing Ruthenium Sulphide (RuS₂) is synthesized together with a self-assembled reduced graphene oxide (RGO) aerogel by a one-pot hydrothermal synthesis. Ruthenium Chloride and L-Cysteine are used as reactants. The hydrothermal synthesis of the innovative hybrid material occurs at 180 °C for 12 h, by using water as solvent. The structure and morphology of the hybrid ...

Dihydroxybenzaldehyde-based Schiff base ligands (L1–L3) and their ruthenium(II) complexes were synthesized and characterized by elemental analysis, 1H-, 13Cand 31P-NMR, UV–Vis, IR and mass spectroscopy. The DNA binding of the ruthenium(II) complexes was investigated by UV–Vis absorption spectroscopy. The experiments revealed that all the compounds could bind to DNA through electrostatic interac...

The electronic spectra, electrical conductivity, magnetism, and gas adsorption properties of the newly prepared Prussian blue analogues Fe4[Ru(CN)6]3 · 18H2O (2) and K1.2Ru3.6[Ru(CN)6]3 · 16H2O (3) are compared with those of Prussian blue itself (Fe4[Fe(CN)6]3 ·14H2O, 1). The increase in the degree of electronic localization for the unsymmetrical iron-ruthenium analogue 2 is reflected in a shif...

Enynes connected through aromatic rings are used as substrates for metathesis reactions. The reactivity of three ruthenium carbene complexes is compared. The resulting 1,3-dienes are suitable precursors of polycyclic structures via a Diels-Alder process. Some domino RCM-Diels-Alder reactions are performed, suggesting a possible beneficial effect of the ruthenium catalyst in the cycloaddition pr...

How can you use a ruthenium isomerization catalyst twice? A ruthenium-catalyzed sequence for the formal two-carbon scission of allyl groups to carboxylic acids has been developed. The reaction includes an initial isomerization step using commercially available ruthenium catalysts followed by in situ transformation of the complex to a metal-oxo species, which is capable of catalyzing subsequent ...