نتایج جستجو برای: rs9939609 polymorphism

تعداد نتایج: 107470  

Journal: :Egyptian Journal of Medical Human Genetics 2023

Abstract Purpose Metabolic syndrome (MetS) is characterized by visceral obesity, elevated blood pressure and fasting glucose, increased triglycerides, lower high-density lipoprotein cholesterol. MetS related with intricate gene-environment interactions. FTO RETN variants were linked to the occurrence of MetS, but inconsistent results reported. Therefore, this study was conducted evaluate potent...

Journal: :The Journal of clinical endocrinology and metabolism 2008
T Berentzen S I I Kring C Holst E Zimmermann T Jess T Hansen O Pedersen S Toubro A Astrup T I A Sørensen

CONTEXT A common variant in the first intron of FTO (rs9939609, T/A) is associated with fatness in Caucasians. OBJECTIVE FTO may regulate energy homeostasis through the hypothalamus, and we hypothesized that AA-genotypes of rs9939609 FTO have lower energy expenditure and/or a lower level of physical activity. METHODS The study population included all obese young men (body mass index > or = ...

2014
Barbara H. Lourenço Lu Qi Walter C. Willett Marly A. Cardoso

Previous evidence suggests that variants in the fat mass and obesity-associated gene (FTO) affect adiposity in an age-dependent fashion in children, and nutritional factors may modify genotype effects. We assessed the effect of FTO rs9939609 on BMI and BMI-for-age Z score changes during childhood in a population-based longitudinal study in the Brazilian Amazon and investigated whether these eff...

2016
Jinjin Wang Jianfeng Zhang Xueqin Xu Lanying Pei Chunyang Sun Xiaohui Liu Ying liu Guoli Yan

Background: We aimed in this study to evaluate the constitution status of Traditional Chinese Medicine (TCM) in metabolic obesity normal weight (MONW) and the genetic effectors of this phenotype from single nucleotide polymorphisms (SNP) and DNA methylation modification. Methods: One to one matched case-control study was conducted in our research. We conducted the standardized Constitution in C...

Journal: :Obesity 2008
Yiqing Song Nai-Chieh You Yi-Hsiang Hsu Barbara V Howard Robert D Langer Joann E Manson Lauren Nathan Tianhua Niu Lesley F Tinker Simin Liu

The FTO gene was recently identified as a susceptibility locus for both obesity and type 2 diabetes by whole-genome association analyses of several European populations. We tested for an association between FTO risk alleles and obesity and diabetes in a well-characterized multiethnic cohort of postmenopausal women in the United States. We genotyped two most significantly associated single-nucle...

Journal: :Obesity 2012
Karani S Vimaleswaran Lars Ängquist Rikke D Hansen Daphne L van der A Nabila Bouatia-Naji Claus Holst Anne Tjønneland Kim Overvad Marianne U Jakobsen Heiner Boeing Karina Meidtner Domenico Palli Giovanna Masala Wim H M Saris Edith J M Feskens Nicholas J Wareham Thorkild I A Sørensen Ruth J F Loos

Although FTO is an established obesity-susceptibility locus, it remains unknown whether it influences weight change in adult life and whether diet attenuates this association. Therefore, we investigated the association of FTO-rs9939609 with changes in weight and waist circumference (WC) during 6.8 years follow-up in a large-scale prospective study and examined whether these associations were mo...

2014
Meixian Zhang Xiaoyuan Zhao Hong Cheng Liang Wang Bo Xi Yue Shen Dongqing Hou Jie Mi

BACKGROUND The associations between common variants in the fat mass- and obesity-associated (FTO) gene and obesity-related traits may be age-dependent and may differ by sex. The present study aimed to assess the association of FTO rs9939609 with body mass index (BMI) and the risk of obesity from childhood to adolescence, and to determine the age at which the association becomes evident. METHO...

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