نتایج جستجو برای: rs9939609 polymorphism
تعداد نتایج: 107470 فیلتر نتایج به سال:
Abstract Purpose Metabolic syndrome (MetS) is characterized by visceral obesity, elevated blood pressure and fasting glucose, increased triglycerides, lower high-density lipoprotein cholesterol. MetS related with intricate gene-environment interactions. FTO RETN variants were linked to the occurrence of MetS, but inconsistent results reported. Therefore, this study was conducted evaluate potent...
CONTEXT A common variant in the first intron of FTO (rs9939609, T/A) is associated with fatness in Caucasians. OBJECTIVE FTO may regulate energy homeostasis through the hypothalamus, and we hypothesized that AA-genotypes of rs9939609 FTO have lower energy expenditure and/or a lower level of physical activity. METHODS The study population included all obese young men (body mass index > or = ...
Previous evidence suggests that variants in the fat mass and obesity-associated gene (FTO) affect adiposity in an age-dependent fashion in children, and nutritional factors may modify genotype effects. We assessed the effect of FTO rs9939609 on BMI and BMI-for-age Z score changes during childhood in a population-based longitudinal study in the Brazilian Amazon and investigated whether these eff...
Background: We aimed in this study to evaluate the constitution status of Traditional Chinese Medicine (TCM) in metabolic obesity normal weight (MONW) and the genetic effectors of this phenotype from single nucleotide polymorphisms (SNP) and DNA methylation modification. Methods: One to one matched case-control study was conducted in our research. We conducted the standardized Constitution in C...
The FTO gene was recently identified as a susceptibility locus for both obesity and type 2 diabetes by whole-genome association analyses of several European populations. We tested for an association between FTO risk alleles and obesity and diabetes in a well-characterized multiethnic cohort of postmenopausal women in the United States. We genotyped two most significantly associated single-nucle...
Although FTO is an established obesity-susceptibility locus, it remains unknown whether it influences weight change in adult life and whether diet attenuates this association. Therefore, we investigated the association of FTO-rs9939609 with changes in weight and waist circumference (WC) during 6.8 years follow-up in a large-scale prospective study and examined whether these associations were mo...
BACKGROUND The associations between common variants in the fat mass- and obesity-associated (FTO) gene and obesity-related traits may be age-dependent and may differ by sex. The present study aimed to assess the association of FTO rs9939609 with body mass index (BMI) and the risk of obesity from childhood to adolescence, and to determine the age at which the association becomes evident. METHO...
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