نتایج جستجو برای: rs12979860

تعداد نتایج: 367  

2015
Jing Chen Wei Wang Xiaoguang Li Jie Xu

BACKGROUND Several association studies with small sample sizes of two SNPs in IL28BB (rs12979860 and rs8099917) showed inconsistent results, so in this study, we aim to evaluate the association between the two SNPs and infection susceptibility of Hepatitis B Virus (HBV) in Asian population, especially in Chinese population by meta-analysis. METHODS Search the relevant published papers and per...

Journal: :hepatitis monthly 0
bita behnava iran hepatitis network, tehran, ir iran; baqiyatallah research center for gastroenterology and liver diseases, baqiyatallah university of medical sciences, tehran, ir iran; middle east liver diseases (meld) center, tehran, ir iran heidar sharafi iran hepatitis network, tehran, ir iran; baqiyatallah research center for gastroenterology and liver diseases, baqiyatallah university of medical sciences, tehran, ir iran; middle east liver diseases (meld) center, tehran, ir iran; armin pathobiology laboratory, tehran, ir iran maryam keshvari iran hepatitis network, tehran, ir iran; blood transfusion research center, high institute for research and education in transfusion medicine, tehran, ir iran ali pouryasin iran hepatitis network, tehran, ir iran; armin pathobiology laboratory, tehran, ir iran; department of biology, arsanjan branch, islamic azad university, arsanjan, ir iran leila mehrnoush iran hepatitis network, tehran, ir iran; middle east liver diseases (meld) center, tehran, ir iran shima salimi iran hepatitis network, tehran, ir iran; middle east liver diseases (meld) center, tehran, ir iran

patients and methods this cross - sectional study was conducted on 143 thalassemic patients with chronic hepatitis c, who were treated with a combination of peg-ifn and rbv regimen. the rs12979860 and rs8099917 polymorphisms were assessed as the most common polymorphisms near the il28b gene by the polymerase chain reaction-restriction fragment length polymorphism (pcr-rflp) method. objectives w...

Journal: :Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2013
Yun Liao Yi Li Bei Cai Jie Chen Lanlan Wang

TO THE EDITOR—We read the article by Seto et al [1] with interest. The authors investigated the correlation of HLA-DP and interleukin 28B (IL-28B) polymorphisms with hepatitis B surface antigen (HBsAg) seroclearance in hepatitis B virus (HBV) patients, and found that IL-28B haplotype CG (rs12979860/rs8099917) was associated with HBsAg clearance. The role of IL-28B polymorphisms in HBV has been ...

2014
Fei Kong Yu Pan Xiumei Chi Xiaomei Wang Linjiao Chen Juan Lv Haibo Sun Ruihong Wu Jinglan Jin Ge Yu Zhenhua Ma Yang Wang Xinxing Huang Hua Li Yang Bai Jing Jia Gerald Y. Minuk Jin Zhong Bing Sun Jing Jiang Junqi Niu

Hepatitis C virus (HCV) infections spontaneously clear in approximately 15-45% of infected individuals. Factors which influence spontaneous HCV clearance remain to be identified. The purpose of the present study was to identify variables associated with spontaneous HCV clearance in a referred population of Chinese patients. The prevalence of host, viral, and environmental factors known to influ...

2015
Bruna C. Bertol Simone Moreira Raquel F. L. Garcia Leslie E. Ferreira Guilherme Debortoli Mauro de Souza Leite Pinho Marcia Amendola-Pires Alessandra M. de Almeida Maciel Carlos E. Brandço-Mello Paulo H. C. de França

INTRODUCTION Single-nucleotide polymorphisms (SNPs) associated with hepatitis C virus (HCV) clearance were identified near the IL28B gene. Coinfection by the human immunodeficiency virus (HIV) influences the course of HCV contributing to liver damage. Nevertheless, little is known about the relationship between these SNPs and HCV/HIV coinfection. Our aim was to estimate the frequencies of the a...

2014
Simone Regina Souza da Silva Conde Julius Caesar Mendes Soares Monteiro Bruna Tereza Silva dos Santos Nathália Karla Fonseca Filgueiras Pedro Alves de Almeida Lins Felipe Bonfim Freitas Ednelza da Silva Graça Sâmia Demachki Marialva Tereza Ferreira de Araújo Ricardo Ishak Antonio Carlos Rosário Vallinoto

AIM The aim of this study was to characterize the genetic profile of patients with chronic hepatitis C virus (HCV) infection relative to polymorphisms rs12979860 and rs8099917 in gene IL28B and the association of those polymorphisms with the response to treatment with pegylated interferon and ribavirin, performed at a reference center in Brazilian Amazonia. METHODS A total of 75 individuals w...

2012
Silvana Gaudieri Michaela Lucas Andrew Lucas Elizabeth McKinnon Hiba Albloushi Andri Rauch Julia di Iulio David Martino Susan L. Prescott Meri K. Tulic

Environmental changes affecting the relationship between the developing immune system and microbial exposure have been implicated in the epidemic rise of allergic disease in developed countries. While early developmental differences in T cell function are well-recognised, there is now emerging evidence that this is related to developmental differences in innate immune function. In this study we...

2012
José A. Agúndez Elena García-Martin María L. Maestro Francisca Cuenca Carmen Martínez Luis Ortega Miguel Carballo Marta Vidaurreta Marta Agreda Gabriela Díaz-Zelaya Avelina Suárez Manuel Díaz-Rubio José M. Ladero

BACKGROUND/AIMS Polymorphism at the IL28B gene may modify the course of hepatitis C virus (HCV) chronic infection. Our aim was to study the influence of IL28B rs12979860 gene polymorphism on the biochemistry and pathology of HCV-induced disease in the clinical course from mild chronic hepatitis C to hepatocellular carcinoma. METHODS We have determined the rs12979860 single nucleotide polymorp...

2015
Gustavo Milson Fabrício-Silva Bruno Silva Poschetzky Renata de Mello Perez Ronaldo Carneiro dos Santos Luciana Tricai Cavalini Luís Cristóvão Porto

BACKGROUND The host immune response is an important indicator of the outcome of hepatitis C virus (HCV) infection and disease progression. The aim of this study was to explore cytokine gene polymorphisms as a candidate for susceptibility to persistent HCV infection or HCV spontaneous clearance in a population from Rio de Janeiro, Brazil. METHODS Genetic polymorphisms in the cytokines, tumor n...

Journal: :hepatitis monthly 0
heidar sharafi iran hepatitis network, tehran, ir iran; middle east liver disease (meld) center, tehran, ir iran; armin pathobiology laboratory, tehran, ir iran seyed moayed alavian iran hepatitis network, tehran, ir iran; middle east liver disease (meld) center, tehran, ir iran bita behnava iran hepatitis network, tehran, ir iran; middle east liver disease (meld) center, tehran, ir iran ali pouryasin iran hepatitis network, tehran, ir iran; armin pathobiology laboratory, tehran, ir iran; department of genetics, islamic azad university-arsanjan branch, arsanjan, ir iran maryam keshvari iran hepatitis network, tehran, ir iran; middle east liver disease (meld) center, tehran, ir iran; blood transfusion research center, high institute for research and education in transfusion medicine, tehran, ir iran; blood transfusion research center, high institute for research and education in transfusion medicine, tehran, ir iran. tel: +98-2188601501, fax: +98-2166900386

materials and methods a case-control study was designed on 91 cases with spontaneous hcv infection clearance and 259 patients with persistent hcv infection as the control group. the rs12979860 snp was assessed as the most common ifnl polymorphism by pcr-rflp method. results distribution of rs12979860 cc genotype in the spontaneous clearance group was around two folds of its distribution in chro...

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