نتایج جستجو برای: rotarod

تعداد نتایج: 966  

2017
Katharina Hohlbaum Bettina Bert Silke Dietze Rupert Palme Heidrun Fink Christa Thöne-Reineke

According to the EU Directive 2010/63, the severity of a procedure has to be classified as mild, moderate or severe. General anesthesia is thought to be mild, but the Directive does not differentiate between single and repeated anesthesia. Therefore, we investigated the impact of repeated administration of isoflurane, the most commonly used inhalation anesthetic, on the well-being of adult C57B...

Masoumeh Emamghoreishi, Sasan Zaeri

Background: N-acetylcysteine (NAC) has been indicated against experimental seizures, but with relatively inconclusive results. This study was undertaken to evaluate whether NAC exerts a dose-dependent anticonvulsant effect and to determine NAC safe therapeutic dose range and its muscle-relaxant activity in both acute and chronic uses.Methods: Following intraperitoneal (i.p.) administration of N...

Journal: :Psicothema 2012
Carol Vasquez Melany Sánchez Jairo Herrera Gabriel Quintero

Studies have shown that N-methyl-D-aspartate (NMDA) receptors play a critical role in pain processing at different levels of the central nervous system. In this study, we used female adult Wistar rats to examine the effects of antagonizing the NR2B subunit of the NMDA receptor in phasic and tonic pain processes. All the rats underwent stereotaxic surgery for cortical cannula implantation and af...

Journal: :Neuropharmacology 2004
D W Cope P Wulff A Oberto M I Aller M Capogna F Ferraguti C Halbsguth H Hoeger H E Jolin A Jones A N J McKenzie W Ogris A Poeltl S T Sinkkonen O Y Vekovischeva E R Korpi W Sieghart E Sigel P Somogyi W Wisden

Agonists of the allosteric benzodiazepine site of GABAA receptors bind at the interface of the alpha and gamma subunits. Here, we tested the in vivo contribution of the gamma2 subunit to the actions of zolpidem, an alpha1 subunit selective benzodiazepine agonist, by generating mice with a phenylalanine (F) to isoleucine (I) substitution at position 77 in the gamma2 subunit. The gamma2F77I mutat...

Journal: :Journal of Huntington's disease 2012
Robert A Cherny Scott Ayton David I Finkelstein Ashley I Bush Gawain McColl Stephen M Massa

BACKGROUND There is evidence that interaction with biologically important metals, particularly copper and iron, contributes to the pathological aggregation and toxicity of the mutant huntingtin protein in HD. PBT2 is a novel 8-hydroxyquinoline drug in clinical trials for AD and HD which restores metal homeostasis and has demonstrated neuroprotective and cognitive benefits in animal models of AD...

2014
Eike Wegener Cornelia Brendel Andre Fischer Swen Hülsmann Jutta Gärtner Peter Huppke

Rett syndrome, one of the most common causes of mental retardation in females, is caused by mutations in the X chromosomal gene MECP2. Mice deficient for MeCP2 recapitulate some of the symptoms seen in patients with Rett syndrome. It has been shown that reactivation of silent MECP2 alleles can reverse some of the symptoms in these mice. We have generated a knockin mouse model for translational ...

2015
Saidah Rauf Sri Kadarsih Soejono Ginus Partadiredja

OBJECTIVES The present study aims at examining the motor coordination performance, serum and cerebellar estrogen, as well as ERβ levels, of ovariectomized rats (as menopausal model) following regular exercise. MATERIALS AND METHODS Ten female Sprague Dawley rats aged 12 weeks old were randomly divided into two groups; all of which underwent ovariectomy. The first group was treated with regula...

2017
Watchara Damjuti Thanes Fuangfoo Chanida Palanuvej Tingli Li Nijsiri Ruangrungsi

Leptocarpus disjunctus Mast. (Restionaceae) is an edible plant which has indigenous warnings regarding its side effects which can manifest as dizziness. This study investigated hypnotic and anxiolytic properties using several animal models. Anxiolytic activities were evaluated using locomotor determination by elevated plus-maze test, open-field test, and rotarod performance test. Hypnotic activ...

Journal: :Neuroscience letters 2014
Maria Rosilene Cândido Moreira Mirian Graciela da Silva Stiebbe Salvadori Antonia Amanda Cardoso de Almeida Damião Pergentino de Sousa Joaquin Jordán Prabodh Satyal Rivelilson Mendes de Freitas Reinaldo Nóbrega de Almeida

The essential oil of Myrtus communis L. (Myrtaceae) and its compounds have been popularly used in numerous health disorders, including insomnia and nervous conditions, but their effects on central nervous system (CNS) have not been explored yet. We evaluated the anxiolytic-like effects and possible action mechanism of (-)-myrtenol (MYR), a monoterpenoid alcohol present in essential oil of M. co...

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