Rosai Dorfman disease is an uncommon benign condition presenting with massive enlargement of cervical lymph nodes. We describe one such young female patient with similar presentation who had an aggressive course with fatal outcome.

RDD (Rosai Dorfman disease) is a rare and benign histiocytic proliferative disorder of unknown etiology. FNAC (Fine-needle aspiration cytology) is a useful and reliable tool for the diagnosis of RDD, and as such, biopsy is avoidable.

Intracranial Rosai-Dorfman disease without systemic involvement is extremely rare. A 59-year-old woman presented with headaches. Magnetic resonance imaging revealed an enhancing posterior fossa convexity lesion with the dural tail sign. The preoperative diagnosis was meningioma. The histopathological examination revealed reactivity for S-100 and CD68 and non-reactivity for CD1a with emperipoles...

Sinus histiocytosis with massive lymphadenopathy or Rosai-Dorfman disease (RDD) is a reactive condition of unknown etiology, characterised by a proliferation of histiocytes exhibiting emperipolesis of lymphocytes and plasma cells. It usually presents as bilateral painless cervical lymphadenopathy. Extranodal RDD without nodal disease is seen in 23% of the cases. Intracranial RDD occurs in less ...

This study reports a clinical case of cutaneous Rosai-Dorfman disease, its manifestation, and its evolution in 10 years, thus contributing to the limited bibliography about it and which review is also an important aim of this paper. This clinical study included a histopathological and immunohistochemical review of the lesions. Since this is a skin disease, not a life-threatening condition, and ...

Sinus histiocytosis with massive lymphadenopathy (SHML) was first described in 1969 by Rosai and Dorfman [1]. It is a rare inflammatory disorder with key clinicopathological characteristics such as emperipolesis and positive immunostaining for S-100 protein [2] and CD68. Rosai–Dorfman disease (RDD) is primarily manifested in the lymph nodes, yet extranodal disease has been reported in as many a...

Sinus histiocytosis with massive lymphadenopathy (SHML) or Rosai-Dorfman disease (RDD) was first described as a distinct clinicopathological entity by Rosai and Dorfman in 1969. SHML is commonly characterized by painless cervical lymphadenopathy, and its clinical course is generally benign and self-limiting. This disorder commonly involves the lymph nodes but may secondarily involve the skin. H...