Background: DprE1, which is a flavoenzyme, very important for cell wall biosynthesis in Mycobacterium tuberculosis (Mtb) and the pathogenesis, virulence, lethality, stress resistance of host. Drug-resistant challenging global human health issue, necessitating development novel, more effective treatment regimens without adverse effects. DprE1 represents potential therapeutic target. It was explo...

In this research, the fourteen commonly used antiviral drugs were investigated through computational tools against CoV-19 or SARS-2, as well two small bioactive molecules from cannabis plant, Tetrahydrocannabinol (THC) and Cannabinol (CBN). Thus, these selelcted for molecular docking main protein (5r7y) spike (6xs6) of coronavirus. It was illustrated that binding energies Mpro Pimodivir, Baloxa...

The available drugs against coronavirus disease 2019 (COVOD-19), caused by severe acute respiratory syndrome 2 (SARS-CoV-2), are limited. This study aimed to identify ginger-derived compounds that might neutralize SARS-CoV-2 and prevent its entry into host cells. Ring of ginger were screened spike (S) protein alpha, beta, gamma, delta variants SARS-CoV-2. S FASTA sequence was retrieved from Glo...

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections have triggered a recent pandemic of disease and affected almost every country all over the world. A large amount natural bioactive compounds are under clinical investigation for various diseases. In particular, marine gaining more attention in new drug development process. The present study aimed to identify potential marin...

TICKBORNE diseases are regionally common problems in dogs, with almost undetectable to fatal clinical manifestations, including fever, weakness, icterus, epistaxis and lameness (May and others 1990, Greig and others 1996, Harrus and others 1997, Pappalardo and others 1997, Greene and Breitschwerdt 1998, Foley and others 2001). In California, important tickborne diseases include Rocky Mountain s...

Statins are the low-density lipoproteins (LDL)-cholesterol-lowering drugs of first choice and used to prevent increased risk cardiovascular cerebrovascular diseases. Although some their effects well known, little is known about ability regulate other lipid-related proteins which control apoptotic mechanisms. The aim this study was explore whether statins can bind cell death-inducing DNA fragmen...

Alzheimer's disease is a progressive age-related brain disorder. It causes gradual memory loss, changes in personality traits, confusion, impaired thinking, and mood Acetylcholinesterase (AChE) butyrylcholinesterase (BuChE) inhibitors have been chosen for the treatment of Alzheimer’s disease. Dual cholinesterase become new hotspot investigation anti-Alzheimer's drugs. The current study was desi...

Coronavirus 19 (COVID-19) is still a global health issue to date, SARS-CoV-2 novel coronavirus that responsible for this sickness. The receptor-binding domain of the virus associates with angiotensin-converting enzyme 2 (ACE-2) and allows enter human cells. Natural peptides such alpha-defensin are thought attach RBD prohibit it from engaging ACE-2. Molecular dynamics simulations using computati...